tetano
Editor, Senior Moderator
J Thorac Dis. 2018 Jul;10(Suppl 19):S2238-S2247. doi: 10.21037/jtd.2017.12.122.
[h=1]Atypical antibody responses to influenza.[/h] Hermans D[SUP]1[/SUP], Webby RJ[SUP]2[/SUP], Wong SS[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza viruses undergo rapid antigenic evolution and reassortment, resulting in annual epidemics and the occasional pandemics. Exposure to influenza virus hemagglutinin (HA) and neuraminidase (NA) antigen, either through vaccination or infection, induces an antibody response able to recognize only the homologous antigenic subtype. However, atypical antibody responses recognizing non-homologous influenza subtypes have been reported during infection and vaccination. Here, we review the incidence of these phenomena in published literature and discuss the potential mechanisms underlying them.
[h=4]KEYWORDS:[/h] Influenza; antibody; heterosubtypic; neutralizing
PMID: 30116603 PMCID: PMC6072921 DOI: 10.21037/jtd.2017.12.122
Free PMC Article
[h=1]Atypical antibody responses to influenza.[/h] Hermans D[SUP]1[/SUP], Webby RJ[SUP]2[/SUP], Wong SS[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza viruses undergo rapid antigenic evolution and reassortment, resulting in annual epidemics and the occasional pandemics. Exposure to influenza virus hemagglutinin (HA) and neuraminidase (NA) antigen, either through vaccination or infection, induces an antibody response able to recognize only the homologous antigenic subtype. However, atypical antibody responses recognizing non-homologous influenza subtypes have been reported during infection and vaccination. Here, we review the incidence of these phenomena in published literature and discuss the potential mechanisms underlying them.
[h=4]KEYWORDS:[/h] Influenza; antibody; heterosubtypic; neutralizing
PMID: 30116603 PMCID: PMC6072921 DOI: 10.21037/jtd.2017.12.122
Free PMC Article