tetano
Editor, Senior Moderator
Clin Immunol. 2019 Mar 25. pii: S1521-6616(19)30130-5. doi: 10.1016/j.clim.2019.03.007. [Epub ahead of print]
[h=1]Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases.[/h] Watad A[SUP]1[/SUP], Bragazzi NL[SUP]2[/SUP], McGonagle D[SUP]3[/SUP], Adawi M[SUP]4[/SUP], Bridgewood C[SUP]3[/SUP], Damiani G[SUP]5[/SUP], Alijotas-Reig J[SUP]6[/SUP], Esteve-Valverde E[SUP]7[/SUP], Quaresma M[SUP]8[/SUP], Amital H[SUP]9[/SUP], Shoenfeld Y[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We investigated the pattern of reported immune diseases in the ASIA registry.
[h=4]METHODS:[/h] Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.
[h=4]RESULTS:[/h] The patient mean age was 43 ? 17 years and 89% were female. Within the reported immune diseases 69% were well defined autoimmune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher that autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked with the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).
[h=4]CONCLUSIONS:[/h] Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
Copyright ? 2019. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] ASIA syndrome; Foreign material; International syndrome registry; Silicone implants; Vaccines
PMID: 30922961 DOI: 10.1016/j.clim.2019.03.007
[h=1]Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases.[/h] Watad A[SUP]1[/SUP], Bragazzi NL[SUP]2[/SUP], McGonagle D[SUP]3[/SUP], Adawi M[SUP]4[/SUP], Bridgewood C[SUP]3[/SUP], Damiani G[SUP]5[/SUP], Alijotas-Reig J[SUP]6[/SUP], Esteve-Valverde E[SUP]7[/SUP], Quaresma M[SUP]8[/SUP], Amital H[SUP]9[/SUP], Shoenfeld Y[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We investigated the pattern of reported immune diseases in the ASIA registry.
[h=4]METHODS:[/h] Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.
[h=4]RESULTS:[/h] The patient mean age was 43 ? 17 years and 89% were female. Within the reported immune diseases 69% were well defined autoimmune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher that autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked with the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).
[h=4]CONCLUSIONS:[/h] Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
Copyright ? 2019. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] ASIA syndrome; Foreign material; International syndrome registry; Silicone implants; Vaccines
PMID: 30922961 DOI: 10.1016/j.clim.2019.03.007