tetano
Editor, Senior Moderator
Virology. 2019 Jan 19;529:101-110. doi: 10.1016/j.virol.2019.01.015. [Epub ahead of print]
[h=1]Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).[/h] Sanada T[SUP]1[/SUP], Yasui F[SUP]2[/SUP], Honda T[SUP]1[/SUP], Kayesh MEH[SUP]3[/SUP], Takano JI[SUP]4[/SUP], Shiogama Y[SUP]4[/SUP], Yasutomi Y[SUP]4[/SUP], Tsukiyama-Kohara K[SUP]3[/SUP], Kohara M[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Avian-origin influenza viruses like H5N1 and H7N9 often cause severe symptoms with high mortality in humans. Animal models are useful for clarification of the mechanisms of pathogenicity of these infections. In this study, to expand the potential utility of the Northern tree shrew (Tupaia belangeri) for influenza virus infection, we assessed the pathogenicity of H5N1 and H7N9 avian influenza viruses in tupaia. Infectious virus was detected continuously from nasal, oral, tracheal, and conjunctival swab samples in the animals infected with these viruses. H5N1 influenza virus infection of tupaia caused severe diffuse pneumonia with fever and weight loss. In contrast, H7N9 influenza virus infection caused focal pneumonia. The severity of pneumonia was correlated with proinflammatory cytokine transcript levels. These results indicated that tupaia can be another suitable animal model for avian influenza virus research.
Copyright ? 2019 The Authors. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Avian influenza virus; H5N1; H7N9; Tree shrew; Tupaia belangeri
PMID: 30684692 DOI: 10.1016/j.virol.2019.01.015
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[h=1]Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).[/h] Sanada T[SUP]1[/SUP], Yasui F[SUP]2[/SUP], Honda T[SUP]1[/SUP], Kayesh MEH[SUP]3[/SUP], Takano JI[SUP]4[/SUP], Shiogama Y[SUP]4[/SUP], Yasutomi Y[SUP]4[/SUP], Tsukiyama-Kohara K[SUP]3[/SUP], Kohara M[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Avian-origin influenza viruses like H5N1 and H7N9 often cause severe symptoms with high mortality in humans. Animal models are useful for clarification of the mechanisms of pathogenicity of these infections. In this study, to expand the potential utility of the Northern tree shrew (Tupaia belangeri) for influenza virus infection, we assessed the pathogenicity of H5N1 and H7N9 avian influenza viruses in tupaia. Infectious virus was detected continuously from nasal, oral, tracheal, and conjunctival swab samples in the animals infected with these viruses. H5N1 influenza virus infection of tupaia caused severe diffuse pneumonia with fever and weight loss. In contrast, H7N9 influenza virus infection caused focal pneumonia. The severity of pneumonia was correlated with proinflammatory cytokine transcript levels. These results indicated that tupaia can be another suitable animal model for avian influenza virus research.
Copyright ? 2019 The Authors. Published by Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Avian influenza virus; H5N1; H7N9; Tree shrew; Tupaia belangeri
PMID: 30684692 DOI: 10.1016/j.virol.2019.01.015
Free full text