tetano
Editor, Senior Moderator
J Infect Dis. 2015 Jun 12. pii: jiv332. [Epub ahead of print]
[h=1]BCG-vaccination enhances immunogenicity of subsequent influenza vaccination in healthy volunteers: a randomized placebo-controlled pilot study.[/h] Leentjens J[SUP]1[/SUP], Kox M[SUP]2[/SUP], Stokman R[SUP]2[/SUP], Gerretsen J[SUP]2[/SUP], Diavatopoulos DA[SUP]3[/SUP], van Crevel R[SUP]4[/SUP], Rimmelzwaan GF[SUP]5[/SUP], Pickkers P[SUP]2[/SUP], Netea MG[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza-related morbidity and mortality remain high. Seasonal vaccination is the backbone of influenza management but does not always result in protective antibody titres. Non-specific effects of BCG-vaccination related to enhanced function of myeloid antigen-presenting cells have been reported. We hypothesized that BCG vaccination could also enhance immune responses to influenza vaccination.
[h=4]METHODS:[/h] Healthy volunteers received either live attenuated BCG vaccine (n=20) or placebo (n=20) in a randomized fashion, followed by intra-muscular injection of trivalent influenza vaccine 14 days later. Hemaglutination inhibiting (HI) antibodies and cellular immunity measured by ex-vivo leukocyte responses were assessed.
[h=4]RESULTS:[/h] In BCG-vaccinated subjects, HI antibody responses against the 2009 pandemic H1N1 vaccine strain were significantly enhanced compared with the placebo group, and there is a trend towards more rapid seroconversion. Additionally, apart from enhanced pro-inflammatory leukocyte responses following BCG vaccination, nonspecific effects of influenza vaccination were also observed, with modulation of cytokine responses against unrelated pathogens.
[h=4]CONCLUSION:[/h] BCG vaccination prior to vaccination with influenza vaccine results in a more pronounced increase and accelerated induction of functional antibody responses against the 2009 pandemic H1N1 influenza vaccine strain. These results may have implications for the design of vaccination strategies and could lead to improvement of vaccination efficacy.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 26071565 [PubMed - as supplied by publisher]
[h=1]BCG-vaccination enhances immunogenicity of subsequent influenza vaccination in healthy volunteers: a randomized placebo-controlled pilot study.[/h] Leentjens J[SUP]1[/SUP], Kox M[SUP]2[/SUP], Stokman R[SUP]2[/SUP], Gerretsen J[SUP]2[/SUP], Diavatopoulos DA[SUP]3[/SUP], van Crevel R[SUP]4[/SUP], Rimmelzwaan GF[SUP]5[/SUP], Pickkers P[SUP]2[/SUP], Netea MG[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza-related morbidity and mortality remain high. Seasonal vaccination is the backbone of influenza management but does not always result in protective antibody titres. Non-specific effects of BCG-vaccination related to enhanced function of myeloid antigen-presenting cells have been reported. We hypothesized that BCG vaccination could also enhance immune responses to influenza vaccination.
[h=4]METHODS:[/h] Healthy volunteers received either live attenuated BCG vaccine (n=20) or placebo (n=20) in a randomized fashion, followed by intra-muscular injection of trivalent influenza vaccine 14 days later. Hemaglutination inhibiting (HI) antibodies and cellular immunity measured by ex-vivo leukocyte responses were assessed.
[h=4]RESULTS:[/h] In BCG-vaccinated subjects, HI antibody responses against the 2009 pandemic H1N1 vaccine strain were significantly enhanced compared with the placebo group, and there is a trend towards more rapid seroconversion. Additionally, apart from enhanced pro-inflammatory leukocyte responses following BCG vaccination, nonspecific effects of influenza vaccination were also observed, with modulation of cytokine responses against unrelated pathogens.
[h=4]CONCLUSION:[/h] BCG vaccination prior to vaccination with influenza vaccine results in a more pronounced increase and accelerated induction of functional antibody responses against the 2009 pandemic H1N1 influenza vaccine strain. These results may have implications for the design of vaccination strategies and could lead to improvement of vaccination efficacy.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 26071565 [PubMed - as supplied by publisher]