tetano
Editor, Senior Moderator
Biochem Biophys Res Commun
. 2021 Jan 1;S0006-291X(20)32281-6.
doi: 10.1016/j.bbrc.2020.12.094. Online ahead of print.
Pathogenesis of COVID-19 and the quality control of nucleic acid detection
Xiao-Dong Mao[SUP] 1 [/SUP], Taiping Li[SUP] 2 [/SUP], Zhirong Xu[SUP] 3 [/SUP], Kangsheng Liu[SUP] 4 [/SUP]
Affiliations
Abstract
The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID-19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied before, false negative results inconsistent with clinical diagnosis have appeared in clinical practice. Therefore, it is urgent to improve the sensitivity of NAT for COVID-19. This study aimed to summarize the current situation and prospect of NAT based on the latest findings on COVID-19 infection. Also, the quality control of sample collection was discussed. Hopefully, this study could help to improve the effectiveness of NAT for COVID-19.
Keywords: Novel coronavirus; Nucleic acid detection technology; Pathogenesis; Quality control; Result interpretation.
. 2021 Jan 1;S0006-291X(20)32281-6.
doi: 10.1016/j.bbrc.2020.12.094. Online ahead of print.
Pathogenesis of COVID-19 and the quality control of nucleic acid detection
Xiao-Dong Mao[SUP] 1 [/SUP], Taiping Li[SUP] 2 [/SUP], Zhirong Xu[SUP] 3 [/SUP], Kangsheng Liu[SUP] 4 [/SUP]
Affiliations
- PMID: 33581843
- DOI: 10.1016/j.bbrc.2020.12.094
Abstract
The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID-19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied before, false negative results inconsistent with clinical diagnosis have appeared in clinical practice. Therefore, it is urgent to improve the sensitivity of NAT for COVID-19. This study aimed to summarize the current situation and prospect of NAT based on the latest findings on COVID-19 infection. Also, the quality control of sample collection was discussed. Hopefully, this study could help to improve the effectiveness of NAT for COVID-19.
Keywords: Novel coronavirus; Nucleic acid detection technology; Pathogenesis; Quality control; Result interpretation.