tetano
Editor, Senior Moderator
Biochim Biophys Acta Mol Basis Dis
. 2023 Feb 27;166671.
doi: 10.1016/j.bbadis.2023.166671. Online ahead of print.
Insight into the mechanisms of coronaviruses evading host innate immunity
Tengteng Yao[SUP] 1 [/SUP], ChingChoon Foo[SUP] 2 [/SUP], Guopei Zheng[SUP] 3 [/SUP], Rui Huang[SUP] 3 [/SUP], Qian Li[SUP] 3 [/SUP], Jianfeng Shen[SUP] 4 [/SUP], Zhaoyang Wang[SUP] 5 [/SUP]
Affiliations
Abstract
The SARS-CoV-2 induced coronavirus disease (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production of interferons (IFNs) in the severe cases were significantly lower than their milder counterparts, suggesting linkage of COVID-19 to impaired innate immunity. This review presents a brief overview of how coronaviruses evade innate immunity, based on the information from SARS-CoV and MERS-CoV. The coronaviruses manage to block, escape, or dampen the innate immune response by antagonizing double-stranded RNA (dsRNA) sensor, stimulator of IFN genes (STING) and mitochondrial antiviral-signaling protein (MAVS) pathways, epigenetic modification, posttranslational modifications, and host mRNA translation. We provide novel insights into a comprehensive therapy to combat SARS-CoV-2 infection.
Keywords: COVID-19; Coronavirus; Epigenetics; Immune evasion; Innate immunity.
. 2023 Feb 27;166671.
doi: 10.1016/j.bbadis.2023.166671. Online ahead of print.
Insight into the mechanisms of coronaviruses evading host innate immunity
Tengteng Yao[SUP] 1 [/SUP], ChingChoon Foo[SUP] 2 [/SUP], Guopei Zheng[SUP] 3 [/SUP], Rui Huang[SUP] 3 [/SUP], Qian Li[SUP] 3 [/SUP], Jianfeng Shen[SUP] 4 [/SUP], Zhaoyang Wang[SUP] 5 [/SUP]
Affiliations
- PMID: 36858323
- DOI: 10.1016/j.bbadis.2023.166671
Abstract
The SARS-CoV-2 induced coronavirus disease (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production of interferons (IFNs) in the severe cases were significantly lower than their milder counterparts, suggesting linkage of COVID-19 to impaired innate immunity. This review presents a brief overview of how coronaviruses evade innate immunity, based on the information from SARS-CoV and MERS-CoV. The coronaviruses manage to block, escape, or dampen the innate immune response by antagonizing double-stranded RNA (dsRNA) sensor, stimulator of IFN genes (STING) and mitochondrial antiviral-signaling protein (MAVS) pathways, epigenetic modification, posttranslational modifications, and host mRNA translation. We provide novel insights into a comprehensive therapy to combat SARS-CoV-2 infection.
Keywords: COVID-19; Coronavirus; Epigenetics; Immune evasion; Innate immunity.