tetano
Editor, Senior Moderator
Bioinformatics
. 2020 Jul 30;btaa691.
doi: 10.1093/bioinformatics/btaa691. Online ahead of print.
Uncovering antibody cross-reaction dynamics in influenza A infections
Gustavo Hernandez-Mejia[SUP] 1 2 [/SUP], Esteban A Hernandez-Vargas[SUP] 1 3 [/SUP]
Affiliations
Abstract
Motivation: Influenza viruses are a cause of large outbreaks and pandemics with high death tolls. A key obstacle is that flu vaccines have inconsistent performance, in the best cases up to 60% effectiveness, but it can be as low as 10%. Uncovering the hidden pathways of how antibodies (Abs) induced by one influenza strain are effective against another, cross-reaction, is a central vexation for the design of universal flu vaccines.
Results: We conceive a stochastic model that successfully represents the antibody cross-reactive data from mice infected with H3N2 influenza strains and further validation with cross-reaction data of H1N1 strains. Using a High-Performance Computing (HPC) cluster, several aspects and parameters in the model were tested. Computational simulations highlight that changes in time of infection and the B-cells population are relevant, however, the affinity threshold of B-cells between consecutive infections is a necessary condition for the successful Abs cross-reaction. Our results suggest a 3-D reformulation of the current influenza antibody landscape for the representation and modeling of cross-reactive data.
Availability: The full code as a testing/simulation platform is freely available here: https://github.com/systemsmedicine/Antibody_cross-reaction_dynamics.
Supplementary information: Supplementary data are available at Bioinformatics online.
. 2020 Jul 30;btaa691.
doi: 10.1093/bioinformatics/btaa691. Online ahead of print.
Uncovering antibody cross-reaction dynamics in influenza A infections
Gustavo Hernandez-Mejia[SUP] 1 2 [/SUP], Esteban A Hernandez-Vargas[SUP] 1 3 [/SUP]
Affiliations
- PMID: 32730562
- DOI: 10.1093/bioinformatics/btaa691
Abstract
Motivation: Influenza viruses are a cause of large outbreaks and pandemics with high death tolls. A key obstacle is that flu vaccines have inconsistent performance, in the best cases up to 60% effectiveness, but it can be as low as 10%. Uncovering the hidden pathways of how antibodies (Abs) induced by one influenza strain are effective against another, cross-reaction, is a central vexation for the design of universal flu vaccines.
Results: We conceive a stochastic model that successfully represents the antibody cross-reactive data from mice infected with H3N2 influenza strains and further validation with cross-reaction data of H1N1 strains. Using a High-Performance Computing (HPC) cluster, several aspects and parameters in the model were tested. Computational simulations highlight that changes in time of infection and the B-cells population are relevant, however, the affinity threshold of B-cells between consecutive infections is a necessary condition for the successful Abs cross-reaction. Our results suggest a 3-D reformulation of the current influenza antibody landscape for the representation and modeling of cross-reactive data.
Availability: The full code as a testing/simulation platform is freely available here: https://github.com/systemsmedicine/Antibody_cross-reaction_dynamics.
Supplementary information: Supplementary data are available at Bioinformatics online.