tetano
Editor, Senior Moderator
Biosci Rep
. 2020 Nov 30;BSR20202690.
doi: 10.1042/BSR20202690. Online ahead of print.
Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical
Xi Zhou[SUP] 1 [/SUP], Dong Chen[SUP] 1 [/SUP], Lan Wang[SUP] 2 [/SUP], Yuanyuan Zhao[SUP] 1 [/SUP], Lai Wei[SUP] 1 [/SUP], Zhishui Chen[SUP] 3 [/SUP], Bo Yang[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) virus is still spreading, finding out the initial hits of viral infection is important to minimize the mild/moderate population, prevent disease aggravation and organs dysfunction. Objective: We investigated COVID-19 patients with different serum calcium levels.
Design: We checked the serum calcium level of the patients based on days after symptom onset as well as the severity of COVID-19. We also checkeed multi-organ injuries and immune cytokines level in their blood.
Results: Both mild/moderate and severe critical cases we observed showed low calcium level in the early stage of viral infection, while the severe/critical cases showed significant lower calcium level than mild/moderate cases in the early stage. We also found that low calcium level related to severe/critical multi-organ injuries especially in the mild/moderate population. Proinflammatory cytokine IL-6 also correlated to calcium change in both mild/moderate and severe/critical cases.
Conclusions: Our finding indicates that calcium balance is a primal hit of COVID-19 and a biomarker of clinical severity at the beginning of symptom onset. Calcium is closely associated with virus-associated multiple organ injuryes and the increase of inflammatory cytokines. Our results provide a new, important indicator of COVID-19 patients from mild/moderate to severe/critical: serum calcium.
Keywords: COVID-19; Multi-organ injury; Pro-inflammatory cytokine; Serum calcium.
. 2020 Nov 30;BSR20202690.
doi: 10.1042/BSR20202690. Online ahead of print.
Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical
Xi Zhou[SUP] 1 [/SUP], Dong Chen[SUP] 1 [/SUP], Lan Wang[SUP] 2 [/SUP], Yuanyuan Zhao[SUP] 1 [/SUP], Lai Wei[SUP] 1 [/SUP], Zhishui Chen[SUP] 3 [/SUP], Bo Yang[SUP] 1 [/SUP]
Affiliations
- PMID: 33252122
- DOI: 10.1042/BSR20202690
Abstract
Background: Coronavirus disease 2019 (COVID-19) virus is still spreading, finding out the initial hits of viral infection is important to minimize the mild/moderate population, prevent disease aggravation and organs dysfunction. Objective: We investigated COVID-19 patients with different serum calcium levels.
Design: We checked the serum calcium level of the patients based on days after symptom onset as well as the severity of COVID-19. We also checkeed multi-organ injuries and immune cytokines level in their blood.
Results: Both mild/moderate and severe critical cases we observed showed low calcium level in the early stage of viral infection, while the severe/critical cases showed significant lower calcium level than mild/moderate cases in the early stage. We also found that low calcium level related to severe/critical multi-organ injuries especially in the mild/moderate population. Proinflammatory cytokine IL-6 also correlated to calcium change in both mild/moderate and severe/critical cases.
Conclusions: Our finding indicates that calcium balance is a primal hit of COVID-19 and a biomarker of clinical severity at the beginning of symptom onset. Calcium is closely associated with virus-associated multiple organ injuryes and the increase of inflammatory cytokines. Our results provide a new, important indicator of COVID-19 patients from mild/moderate to severe/critical: serum calcium.
Keywords: COVID-19; Multi-organ injury; Pro-inflammatory cytokine; Serum calcium.