tetano
Editor, Senior Moderator
Biotechnol Appl Biochem
. 2024 May 6.
doi: 10.1002/bab.2597. Online ahead of print. Evaluation of the therapeutic action of original antiviral drug in SARS-CoV-2
Arthur K Melkonian[SUP] 1 [/SUP], Gagik V Hakobyan[SUP] 2 [/SUP]
Affiliations
Purpose of this article is to study the possible direct antiviral effect of "Armenikum" on SARS-CoV-2, conduct an in vitro study on the SARS-CoV-2 encephalomocarditis virus, and an in vivo study on the Syrian hamster model. Human coronavirus SARS-CoV-2 (delta strain) was used as the virus. Two groups of four-specimen hamsters were used to study the therapeutic activity of the drug during 48 h after infecting. One group of hamsters served as positive control and was infected with the virus at a similar dose as experimental one and was used as a control of pathology induced by the viral infection till the end of the experiment. Another group of hamsters (four of them) was injected physiological solution and was used as a control. The Syrian hamsters underwent a clinical blood test and computed tomography. "Armenikum" in the form of an injection has a significant antiviral effect on the human coronavirus SARS-CoV-2, credibly reducing the titers of the virus and the time of its elimination from the Syrian hamsters, significantly mitigating the viral infection. "Armenikum" in the form of an injection drug almost completely removes the pathological effect of the virus in the lungs of the hamsters.
Keywords: SARS‐CoV‐2; antiviral therapeutic action; “Armenikum,” dextrin.
. 2024 May 6.
doi: 10.1002/bab.2597. Online ahead of print. Evaluation of the therapeutic action of original antiviral drug in SARS-CoV-2
Arthur K Melkonian[SUP] 1 [/SUP], Gagik V Hakobyan[SUP] 2 [/SUP]
Affiliations
- PMID: 38710664
- DOI: 10.1002/bab.2597
Purpose of this article is to study the possible direct antiviral effect of "Armenikum" on SARS-CoV-2, conduct an in vitro study on the SARS-CoV-2 encephalomocarditis virus, and an in vivo study on the Syrian hamster model. Human coronavirus SARS-CoV-2 (delta strain) was used as the virus. Two groups of four-specimen hamsters were used to study the therapeutic activity of the drug during 48 h after infecting. One group of hamsters served as positive control and was infected with the virus at a similar dose as experimental one and was used as a control of pathology induced by the viral infection till the end of the experiment. Another group of hamsters (four of them) was injected physiological solution and was used as a control. The Syrian hamsters underwent a clinical blood test and computed tomography. "Armenikum" in the form of an injection has a significant antiviral effect on the human coronavirus SARS-CoV-2, credibly reducing the titers of the virus and the time of its elimination from the Syrian hamsters, significantly mitigating the viral infection. "Armenikum" in the form of an injection drug almost completely removes the pathological effect of the virus in the lungs of the hamsters.
Keywords: SARS‐CoV‐2; antiviral therapeutic action; “Armenikum,” dextrin.