tetano
Editor, Senior Moderator
BJOG
. 2021 Oct 17.
doi: 10.1111/1471-0528.16969. Online ahead of print.
Pregnancy and risk of COVID-19: a Norwegian registry-linkage study
Maria C Magnus[SUP] 1 2 [/SUP], Laura Oakley[SUP] 1 3 [/SUP], Håkon K Gjessing[SUP] 1 4 [/SUP], Olof Stephansson[SUP] 5 6 [/SUP], Hilde M Engjom[SUP] 7 8 [/SUP], Ferenc Macsali[SUP] 7 8 [/SUP], Petur B Juliusson[SUP] 7 9 [/SUP], Anne-Marie Nybo Andersen[SUP] 10 [/SUP], Siri E Håberg[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist health-care services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.
Population or sample: All women ages 15 to 45 living in Norway on March 1[SUP]st[/SUP] , 2020 (N=1,033,699).
Methods: We linked information from the national birth, patient, communicable diseases, and education databases using unique national identifiers.
Main outcome measure: We estimated hazard ratios (HR) among pregnant compared to non-pregnant women of having a positive test for SARS-CoV-2, a diagnosis of COVID-19 in specialist healthcare, or hospitalization with COVID-19 using Cox regression. Multivariable analyses adjusted for age, marital status, education, income, country of birth and underlying medical conditions.
Results: Pregnant women were not more likely to be tested for or to a have a positive SARS-CoV-2 test (adjusted HR, 0.99; 95% confidence interval [CI]: 0.92-1.07). Pregnant women had higher risk of hospitalization with COVID-19 (HR, 4.70; 95% CI: 3.51- 6.30), and any type of specialist care for COVID-19 (HR, 3.46; 95% CI: 2.89-4.14). Pregnant women born outside Scandinavia were less likely to be tested, and at higher risk of a positive test (HR, 2.37; 95% CI: 2.51-8.87). Compared to pregnant Scandinavian born women, pregnant women with minority background had a higher risk of hospitalization with COVID-19 (HR, 4.72; 95% CI: 2.51-8.87).
Conclusion: Pregnant women were not more likely to be infected with SARS-CoV-2. Still, pregnant women with COVID-19, especially those born outside of Scandinavia, were more likely to be hospitalized.
Keywords: COVID-19; SARS-CoV-2; pregnancy.
. 2021 Oct 17.
doi: 10.1111/1471-0528.16969. Online ahead of print.
Pregnancy and risk of COVID-19: a Norwegian registry-linkage study
Maria C Magnus[SUP] 1 2 [/SUP], Laura Oakley[SUP] 1 3 [/SUP], Håkon K Gjessing[SUP] 1 4 [/SUP], Olof Stephansson[SUP] 5 6 [/SUP], Hilde M Engjom[SUP] 7 8 [/SUP], Ferenc Macsali[SUP] 7 8 [/SUP], Petur B Juliusson[SUP] 7 9 [/SUP], Anne-Marie Nybo Andersen[SUP] 10 [/SUP], Siri E Håberg[SUP] 1 [/SUP]
Affiliations
- PMID: 34657368
- DOI: 10.1111/1471-0528.16969
Abstract
Objective: To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist health-care services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.
Population or sample: All women ages 15 to 45 living in Norway on March 1[SUP]st[/SUP] , 2020 (N=1,033,699).
Methods: We linked information from the national birth, patient, communicable diseases, and education databases using unique national identifiers.
Main outcome measure: We estimated hazard ratios (HR) among pregnant compared to non-pregnant women of having a positive test for SARS-CoV-2, a diagnosis of COVID-19 in specialist healthcare, or hospitalization with COVID-19 using Cox regression. Multivariable analyses adjusted for age, marital status, education, income, country of birth and underlying medical conditions.
Results: Pregnant women were not more likely to be tested for or to a have a positive SARS-CoV-2 test (adjusted HR, 0.99; 95% confidence interval [CI]: 0.92-1.07). Pregnant women had higher risk of hospitalization with COVID-19 (HR, 4.70; 95% CI: 3.51- 6.30), and any type of specialist care for COVID-19 (HR, 3.46; 95% CI: 2.89-4.14). Pregnant women born outside Scandinavia were less likely to be tested, and at higher risk of a positive test (HR, 2.37; 95% CI: 2.51-8.87). Compared to pregnant Scandinavian born women, pregnant women with minority background had a higher risk of hospitalization with COVID-19 (HR, 4.72; 95% CI: 2.51-8.87).
Conclusion: Pregnant women were not more likely to be infected with SARS-CoV-2. Still, pregnant women with COVID-19, especially those born outside of Scandinavia, were more likely to be hospitalized.
Keywords: COVID-19; SARS-CoV-2; pregnancy.