tetano
Editor, Senior Moderator
Blood Purif
. 2020 Jul 13;1-8.
doi: 10.1159/000508657. Online ahead of print.
Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy
Evgeny V Fominskiy[SUP] 1 [/SUP], Anna Mara Scandroglio[SUP] 1 [/SUP], Giacomo Monti[SUP] 1 [/SUP], Maria Grazia Calabr?[SUP] 1 [/SUP], Giovanni Landoni[SUP] 2 3 [/SUP], Antonio Dell'Acqua[SUP] 1 [/SUP], Luigi Beretta[SUP] 1 [/SUP], Elena Moizo[SUP] 1 [/SUP], Alfredo Ravizza[SUP] 1 [/SUP], Fabrizio Monaco[SUP] 1 [/SUP], Corrado Campochiaro[SUP] 4 [/SUP], Marina Pieri[SUP] 1 [/SUP], Maria Luisa Azzolini[SUP] 1 [/SUP], Giovanni Borghi[SUP] 1 [/SUP], Martina Crivellari[SUP] 1 [/SUP], Caterina Conte[SUP] 5 6 [/SUP], Cristina Mattioli[SUP] 1 [/SUP], Paolo Silvani[SUP] 1 [/SUP], Milena Mucci[SUP] 1 [/SUP], Stefano Turi[SUP] 1 [/SUP], Stefano Tentori[SUP] 7 [/SUP], Martina Baiardo Redaelli[SUP] 1 [/SUP], Marianna Sartorelli[SUP] 1 [/SUP], Piera Angelillo[SUP] 8 [/SUP], Alessandro Belletti[SUP] 1 [/SUP], Pasquale Nardelli[SUP] 1 [/SUP], Francesco Giuseppe Nisi[SUP] 1 [/SUP], Gabriele Valsecchi[SUP] 1 [/SUP], Cristina Barberio[SUP] 1 [/SUP], Fabio Ciceri[SUP] 5 8 [/SUP], Ary Serpa Neto[SUP] 9 10 11 [/SUP], Lorenzo Dagna[SUP] 5 4 [/SUP], Rinaldo Bellomo[SUP] 9 12 13 14 11 [/SUP], Alberto Zangrillo[SUP] 1 5 [/SUP], COVID-BioB Study Group
Affiliations
Abstract
Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems.
Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients.
Methods: Observational study in a tertiary care hospital in Milan, Italy.
Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients.
Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
Keywords: Acute kidney injury; Coronavirus; Coronavirus disease 2019; Critical care; Renal replacement therapy.
. 2020 Jul 13;1-8.
doi: 10.1159/000508657. Online ahead of print.
Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy
Evgeny V Fominskiy[SUP] 1 [/SUP], Anna Mara Scandroglio[SUP] 1 [/SUP], Giacomo Monti[SUP] 1 [/SUP], Maria Grazia Calabr?[SUP] 1 [/SUP], Giovanni Landoni[SUP] 2 3 [/SUP], Antonio Dell'Acqua[SUP] 1 [/SUP], Luigi Beretta[SUP] 1 [/SUP], Elena Moizo[SUP] 1 [/SUP], Alfredo Ravizza[SUP] 1 [/SUP], Fabrizio Monaco[SUP] 1 [/SUP], Corrado Campochiaro[SUP] 4 [/SUP], Marina Pieri[SUP] 1 [/SUP], Maria Luisa Azzolini[SUP] 1 [/SUP], Giovanni Borghi[SUP] 1 [/SUP], Martina Crivellari[SUP] 1 [/SUP], Caterina Conte[SUP] 5 6 [/SUP], Cristina Mattioli[SUP] 1 [/SUP], Paolo Silvani[SUP] 1 [/SUP], Milena Mucci[SUP] 1 [/SUP], Stefano Turi[SUP] 1 [/SUP], Stefano Tentori[SUP] 7 [/SUP], Martina Baiardo Redaelli[SUP] 1 [/SUP], Marianna Sartorelli[SUP] 1 [/SUP], Piera Angelillo[SUP] 8 [/SUP], Alessandro Belletti[SUP] 1 [/SUP], Pasquale Nardelli[SUP] 1 [/SUP], Francesco Giuseppe Nisi[SUP] 1 [/SUP], Gabriele Valsecchi[SUP] 1 [/SUP], Cristina Barberio[SUP] 1 [/SUP], Fabio Ciceri[SUP] 5 8 [/SUP], Ary Serpa Neto[SUP] 9 10 11 [/SUP], Lorenzo Dagna[SUP] 5 4 [/SUP], Rinaldo Bellomo[SUP] 9 12 13 14 11 [/SUP], Alberto Zangrillo[SUP] 1 5 [/SUP], COVID-BioB Study Group
Affiliations
- PMID: 32659757
- DOI: 10.1159/000508657
Abstract
Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems.
Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients.
Methods: Observational study in a tertiary care hospital in Milan, Italy.
Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients.
Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
Keywords: Acute kidney injury; Coronavirus; Coronavirus disease 2019; Critical care; Renal replacement therapy.