tetano
Editor, Senior Moderator
BMC Geriatr
. 2024 Jan 11;24(1):51.
doi: 10.1186/s12877-023-04626-2. Clinical characteristics of patients hospitalized for COVID-19: comparison between different age groups
Ginevra Fabiani[SUP] 1 [/SUP], Carolina Cogozzo[SUP] 1 [/SUP], Anna De Paris[SUP] 1 [/SUP], Valentina Di Maria[SUP] 1 [/SUP], Alessia Lagomarsini[SUP] 1 [/SUP], Olimpia Masotti[SUP] 1 [/SUP], Simona Matteini[SUP] 1 [/SUP], Elisa Paolucci[SUP] 1 [/SUP], Lorenzo Pelagatti[SUP] 1 [/SUP], Francesco Pepe[SUP] 1 [/SUP], Maurizio Villanti[SUP] 1 [/SUP], Francesca Todde[SUP] 1 [/SUP], Riccardo Pini[SUP] 1 [/SUP], Francesca Innocenti[SUP] 2 [/SUP]
Affiliations
Background: To test whether known prognosticators of COVID-19 maintained their stratification ability across age groups.
Methods: We performed a retrospective study. We included all patients (n = 2225), who presented to the Emergency Department of the Careggi University Hospital for COVID-19 in the period February 2020-May 2021, and were admitted to the hospital. The following parameters were analyzed as dichotomized: 1) SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ≤ or > 214; 2) creatinine < or ≥ 1.1 mg/dL; 3) Lactic dehydrogenase (LDH) < or ≥ 250 U/mL; 4) C Reactive Protein (CRP) < or ≥ 60 mg/100 mL. We divided the study population in four subgroups, based on the quartiles of distribution of age (G1 18-57 years, G2 57-71 years, G3 72-81 years, G4 > 82). The primary end-point was in-hospital mortality.
Results: By the univariate analysis, the aforementioned dichotomized variables demonstrated a significant association with in-hospital mortality in all subgroups. We introduced them in a multivariate model: in G1 SpO2/FiO2 ≤ 214 (Relative Risk, RR 15.66; 95%CI 3.98-61,74), in G2 creatinine ≥ 1.1 mg/L (RR 2.87, 95%CI 1.30-6.32) and LDH ≥ 250 UI/L (RR 8.71, 95%CI 1,15-65,70), in G3 creatinine ≥ 1.1 mg/L (RR 1.98, 95%CI 1,17-3.36) and CRP ≥ 60 ng/L (RR 2.14, 95%CI 1.23-3.71), in G4 SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ≤ 214 (RR 5.15, 95%CI 2.35-11.29), creatinine ≥ 1.1 mg/L (RR 1.75, 95%CI 1.09-2.80) and CRP ≥ 60 ng/L (RR 1.82, 95%CI 1.11-2.98) were independently associated with an increased in-hospital mortality.
Conclusions: A mild to moderate respiratory failure showed an independent association with an increased mortality rate only in youngest and oldest patients, while kidney disease maintained a prognostic role regardless of age.
Keywords: COVID-19; Mortality rate; Prognostic scores; Respiratory failure.
. 2024 Jan 11;24(1):51.
doi: 10.1186/s12877-023-04626-2. Clinical characteristics of patients hospitalized for COVID-19: comparison between different age groups
Ginevra Fabiani[SUP] 1 [/SUP], Carolina Cogozzo[SUP] 1 [/SUP], Anna De Paris[SUP] 1 [/SUP], Valentina Di Maria[SUP] 1 [/SUP], Alessia Lagomarsini[SUP] 1 [/SUP], Olimpia Masotti[SUP] 1 [/SUP], Simona Matteini[SUP] 1 [/SUP], Elisa Paolucci[SUP] 1 [/SUP], Lorenzo Pelagatti[SUP] 1 [/SUP], Francesco Pepe[SUP] 1 [/SUP], Maurizio Villanti[SUP] 1 [/SUP], Francesca Todde[SUP] 1 [/SUP], Riccardo Pini[SUP] 1 [/SUP], Francesca Innocenti[SUP] 2 [/SUP]
Affiliations
- PMID: 38212683
- PMCID: PMC10785440
- DOI: 10.1186/s12877-023-04626-2
Background: To test whether known prognosticators of COVID-19 maintained their stratification ability across age groups.
Methods: We performed a retrospective study. We included all patients (n = 2225), who presented to the Emergency Department of the Careggi University Hospital for COVID-19 in the period February 2020-May 2021, and were admitted to the hospital. The following parameters were analyzed as dichotomized: 1) SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ≤ or > 214; 2) creatinine < or ≥ 1.1 mg/dL; 3) Lactic dehydrogenase (LDH) < or ≥ 250 U/mL; 4) C Reactive Protein (CRP) < or ≥ 60 mg/100 mL. We divided the study population in four subgroups, based on the quartiles of distribution of age (G1 18-57 years, G2 57-71 years, G3 72-81 years, G4 > 82). The primary end-point was in-hospital mortality.
Results: By the univariate analysis, the aforementioned dichotomized variables demonstrated a significant association with in-hospital mortality in all subgroups. We introduced them in a multivariate model: in G1 SpO2/FiO2 ≤ 214 (Relative Risk, RR 15.66; 95%CI 3.98-61,74), in G2 creatinine ≥ 1.1 mg/L (RR 2.87, 95%CI 1.30-6.32) and LDH ≥ 250 UI/L (RR 8.71, 95%CI 1,15-65,70), in G3 creatinine ≥ 1.1 mg/L (RR 1.98, 95%CI 1,17-3.36) and CRP ≥ 60 ng/L (RR 2.14, 95%CI 1.23-3.71), in G4 SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] ≤ 214 (RR 5.15, 95%CI 2.35-11.29), creatinine ≥ 1.1 mg/L (RR 1.75, 95%CI 1.09-2.80) and CRP ≥ 60 ng/L (RR 1.82, 95%CI 1.11-2.98) were independently associated with an increased in-hospital mortality.
Conclusions: A mild to moderate respiratory failure showed an independent association with an increased mortality rate only in youngest and oldest patients, while kidney disease maintained a prognostic role regardless of age.
Keywords: COVID-19; Mortality rate; Prognostic scores; Respiratory failure.