tetano
Editor, Senior Moderator
BMC Immunol
. 2022 Sep 5;23(1):40.
doi: 10.1186/s12865-022-00516-1.
Cycling and activated CD8 [SUP]+[/SUP] T lymphocytes and their association with disease severity in influenza patients
Shuai Liu[SUP] #[/SUP][SUP] 1 2 [/SUP], Zhisheng Huang[SUP] #[/SUP][SUP] 3 4 [/SUP], Ruyue Fan[SUP] 5 [/SUP], Ju Jia[SUP] 3 4 [/SUP], Xiaoyan Deng[SUP] 6 [/SUP], Xiaohui Zou[SUP] 3 4 [/SUP], Hui Li[SUP] 3 4 [/SUP], Bin Cao[SUP] 7 8 9 [/SUP]
Affiliations
Abstract
Background: T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity.
Methods: In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry.
Results: The numbers of cycling (Ki67[SUP]+[/SUP]) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO[SUP]+[/SUP]) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation during the acute phase of influenza infection. The recruitment of cycling and activated (CD38[SUP]+[/SUP]HLA-DR[SUP]+[/SUP]) CD8[SUP]+[/SUP] T cells subset is delayed in severe influenza patients.
Conclusions: The increased numbers of cycling memory (Ki67[SUP]+[/SUP]CD45RO[SUP]+[/SUP]) T cells subsets and delayed kinetics of activated (CD38[SUP]+[/SUP]HLA-DR[SUP]+[/SUP]) CD8[SUP]+[/SUP] T cells, could serve as possible biological markers for disease severity.
Keywords: Cell cycle; Severe influenza infection; T cell function.
. 2022 Sep 5;23(1):40.
doi: 10.1186/s12865-022-00516-1.
Cycling and activated CD8 [SUP]+[/SUP] T lymphocytes and their association with disease severity in influenza patients
Shuai Liu[SUP] #[/SUP][SUP] 1 2 [/SUP], Zhisheng Huang[SUP] #[/SUP][SUP] 3 4 [/SUP], Ruyue Fan[SUP] 5 [/SUP], Ju Jia[SUP] 3 4 [/SUP], Xiaoyan Deng[SUP] 6 [/SUP], Xiaohui Zou[SUP] 3 4 [/SUP], Hui Li[SUP] 3 4 [/SUP], Bin Cao[SUP] 7 8 9 [/SUP]
Affiliations
- PMID: 36064355
- DOI: 10.1186/s12865-022-00516-1
Abstract
Background: T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity.
Methods: In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry.
Results: The numbers of cycling (Ki67[SUP]+[/SUP]) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO[SUP]+[/SUP]) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation during the acute phase of influenza infection. The recruitment of cycling and activated (CD38[SUP]+[/SUP]HLA-DR[SUP]+[/SUP]) CD8[SUP]+[/SUP] T cells subset is delayed in severe influenza patients.
Conclusions: The increased numbers of cycling memory (Ki67[SUP]+[/SUP]CD45RO[SUP]+[/SUP]) T cells subsets and delayed kinetics of activated (CD38[SUP]+[/SUP]HLA-DR[SUP]+[/SUP]) CD8[SUP]+[/SUP] T cells, could serve as possible biological markers for disease severity.
Keywords: Cell cycle; Severe influenza infection; T cell function.