tetano
Editor, Senior Moderator
BMC Infect Dis
. 2020 Sep 22;20(1):695.
doi: 10.1186/s12879-020-05423-7.
Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: a retrospective case series
Tao Yao[SUP] 1 2 [/SUP], Yan Gao[SUP] 1 2 [/SUP], Qin Cui[SUP] 1 2 [/SUP], Bo Peng[SUP] 1 2 [/SUP], Yan Chen[SUP] 1 2 [/SUP], Jiansheng Li[SUP] 1 2 [/SUP], Chao Huang[SUP] 1 3 [/SUP], Chunping He[SUP] 1 3 [/SUP], Jie Pu[SUP] 1 2 [/SUP], Jiajun Wei[SUP] 1 2 [/SUP], Yanqiang Zhan[SUP] 1 2 [/SUP], Jie Yan[SUP] 1 4 [/SUP], Jinghua Tian[SUP] 1 5 [/SUP], Zhaohui Zhang[SUP] 6 7 [/SUP], Zhichao Liu[SUP] 8 9 [/SUP]
Affiliations
Abstract
Background: With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and more death cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinical characteristics of deaths with COVID-19 pneumonia.
Methods: We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia in East Hospital of Wuhan University Renmin Hospital, between January 26, 2020, and February 28, 2020.
Results: Of the 83 deaths, none was the medical staff. The mean age was 71.8 years (SD 13.2; range, 34-97 years) and 53(63.9%) were male. The median from onset to admission was 10 days (IQR 7-14: range, 2-43 days), to death was 17 days (IQR 14-21: range, 6-54 days). Most deaths (66[80%]) had underlying comorbid diseases, the most of which was hypertension [47(57%)]. The main initial symptoms of these 83 deaths were shortness of breath(98.8%), fever(94%), and myalgia or fatigue(90.4%). Laboratory analyses showed the lymphocytopenia in 69(83%) deaths, hypoalbuminemia in 77(93%) deaths, the elevation of lactate dehydrogenase in 79(95%) deaths, procalcitonin in 69(83%) deaths and C-reactive protein in 79(95%) deaths. All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, 54(65.1%) deaths received glucocorticoid therapy, and 20(24.1%) patients received invasive mechanical ventilation.
Conclusion: Most of the deaths with COVID-19 pneumonia were elderly patients with underlying comorbid diseases, especially those over 70 years of age. The time of death after the onset of the disease was mostly 15-21 days. More care should be given to the elderly in further prevention and control strategies of COVID-19.
Keywords: COVID-19; Characteristics; Death; Pneumonia.
. 2020 Sep 22;20(1):695.
doi: 10.1186/s12879-020-05423-7.
Clinical characteristics of a group of deaths with COVID-19 pneumonia in Wuhan, China: a retrospective case series
Tao Yao[SUP] 1 2 [/SUP], Yan Gao[SUP] 1 2 [/SUP], Qin Cui[SUP] 1 2 [/SUP], Bo Peng[SUP] 1 2 [/SUP], Yan Chen[SUP] 1 2 [/SUP], Jiansheng Li[SUP] 1 2 [/SUP], Chao Huang[SUP] 1 3 [/SUP], Chunping He[SUP] 1 3 [/SUP], Jie Pu[SUP] 1 2 [/SUP], Jiajun Wei[SUP] 1 2 [/SUP], Yanqiang Zhan[SUP] 1 2 [/SUP], Jie Yan[SUP] 1 4 [/SUP], Jinghua Tian[SUP] 1 5 [/SUP], Zhaohui Zhang[SUP] 6 7 [/SUP], Zhichao Liu[SUP] 8 9 [/SUP]
Affiliations
- PMID: 32962639
- DOI: 10.1186/s12879-020-05423-7
Abstract
Background: With the widespread outbreak of novel coronavirus diseases 2019(COVID-19), more and more death cases were reported, however, limited data are available for the patients who died. We aimed to explore the clinical characteristics of deaths with COVID-19 pneumonia.
Methods: We abstracted and analyzed epidemiological, demographic, clinical, and laboratory data from 83 death cases with COVID-19 pneumonia in East Hospital of Wuhan University Renmin Hospital, between January 26, 2020, and February 28, 2020.
Results: Of the 83 deaths, none was the medical staff. The mean age was 71.8 years (SD 13.2; range, 34-97 years) and 53(63.9%) were male. The median from onset to admission was 10 days (IQR 7-14: range, 2-43 days), to death was 17 days (IQR 14-21: range, 6-54 days). Most deaths (66[80%]) had underlying comorbid diseases, the most of which was hypertension [47(57%)]. The main initial symptoms of these 83 deaths were shortness of breath(98.8%), fever(94%), and myalgia or fatigue(90.4%). Laboratory analyses showed the lymphocytopenia in 69(83%) deaths, hypoalbuminemia in 77(93%) deaths, the elevation of lactate dehydrogenase in 79(95%) deaths, procalcitonin in 69(83%) deaths and C-reactive protein in 79(95%) deaths. All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, 54(65.1%) deaths received glucocorticoid therapy, and 20(24.1%) patients received invasive mechanical ventilation.
Conclusion: Most of the deaths with COVID-19 pneumonia were elderly patients with underlying comorbid diseases, especially those over 70 years of age. The time of death after the onset of the disease was mostly 15-21 days. More care should be given to the elderly in further prevention and control strategies of COVID-19.
Keywords: COVID-19; Characteristics; Death; Pneumonia.