tetano
Editor, Senior Moderator
BMC Infect Dis
. 2021 Feb 24;21(1):207.
doi: 10.1186/s12879-021-05897-z.
Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study
Hua Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Feng Du[SUP] 2 [/SUP], Xiao-Jun Cao[SUP] 1 [/SUP], Xia-Long Feng[SUP] 3 [/SUP], He-Ping Zhang[SUP] 1 [/SUP], Zheng-Xia Wu[SUP] 1 [/SUP], Bao-Feng Wang[SUP] 1 [/SUP], Hong-Juan Zhang[SUP] 1 [/SUP], Rui Liu[SUP] 1 [/SUP], Jian-Jun Yang[SUP] 2 [/SUP], Bo Ning[SUP] 2 [/SUP], Kai Chen[SUP] 4 [/SUP], Zhen-Peng Huang[SUP] #[/SUP][SUP] 5 [/SUP]
Affiliations
Abstract
Background: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China.
Methods: Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe).
Results: Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05).
Conclusion: Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.
Keywords: 2019-nCoV; COVID-19; China; Clinical characteristics; Wuhan.
. 2021 Feb 24;21(1):207.
doi: 10.1186/s12879-021-05897-z.
Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study
Hua Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Feng Du[SUP] 2 [/SUP], Xiao-Jun Cao[SUP] 1 [/SUP], Xia-Long Feng[SUP] 3 [/SUP], He-Ping Zhang[SUP] 1 [/SUP], Zheng-Xia Wu[SUP] 1 [/SUP], Bao-Feng Wang[SUP] 1 [/SUP], Hong-Juan Zhang[SUP] 1 [/SUP], Rui Liu[SUP] 1 [/SUP], Jian-Jun Yang[SUP] 2 [/SUP], Bo Ning[SUP] 2 [/SUP], Kai Chen[SUP] 4 [/SUP], Zhen-Peng Huang[SUP] #[/SUP][SUP] 5 [/SUP]
Affiliations
- PMID: 33627079
- DOI: 10.1186/s12879-021-05897-z
Abstract
Background: A large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China.
Methods: Thirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe).
Results: Nine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05).
Conclusion: Most cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.
Keywords: 2019-nCoV; COVID-19; China; Clinical characteristics; Wuhan.