tetano
Editor, Senior Moderator
BMC Infect Dis
. 2021 May 4;21(1):412.
doi: 10.1186/s12879-021-06068-w.
Comparative study of hospitalized children with acute respiratory distress syndrome caused by SARS-CoV-2 and influenza virus
Xinghua Liu[SUP] #[/SUP][SUP] 1 [/SUP], Wei Li[SUP] #[/SUP][SUP] 1 [/SUP], Bo Zhang[SUP] #[/SUP][SUP] 2 [/SUP], Yan Guo[SUP] #[/SUP][SUP] 3 [/SUP], Zhao Hu[SUP] 4 [/SUP], Cao Peng[SUP] 5 [/SUP], Xiao Lei[SUP] 6 [/SUP], Qunying Luo[SUP] 6 [/SUP], Qiong Zhang[SUP] 6 [/SUP], Wei Deng[SUP] 6 [/SUP], Juanjuan Wang[SUP] 7 [/SUP], Jianqiao Tang[SUP] 8 [/SUP], Yunqiao Li[SUP] 9 [/SUP], Jianying Chen[SUP] 10 [/SUP]
Affiliations
Abstract
Background: Since the outbreak of coronavirus disease 2019 in December 2019, more than 8 million cases have occurred worldwide as of June 16, 2020. However, it is important to distinguish COVID-19 from other respiratory infectious diseases, such as influenza. Here, we comparatively described the clinical characteristics of children with COVID-19 and paediatric patients with influenza.
Methods: In this retrospective, single-centre study, we reviewed the electronic medical records of 585 paediatric patients with COVID-19 or influenza in Wuhan Children's Hospital, China. Clinical and epidemiological characteristics, laboratory findings, and clinical outcomes were comparatively analysed.
Results: The median ages were 6.96 years (IQR, 2-10.81) for children with confirmed COVID-19, 2.67 years (IQR, 1.03-15.25) for those with influenza A and 3.67 years (IQR, 1.62-5.54) for those with influenza B. Fever was a symptom in 84 (34.7%) COVID-19 cases, 132 (70.21%) influenza A cases and 111 (74.50%) influenza B cases. The median length of stay (LOS) was 11 (8-15) days for paediatric COVID-19 patients, 4 (3-6) days for influenza A patients and 5 (3-6) days for influenza B patients. Twenty-six (13.98%) influenza A patients and 18 (12.59%) influenza B patients presented with decreased white blood cell counts, while 13 (5.33%) COVID-19 patients presented with decreased white blood cell counts. Eight (3.28%) COVID-19 patients, 23 (12.71%) influenza A patients and 21 (14.79%) influenza B patients experienced lymphocytopenia. Acute cardiac injury occurred in 18 (7.29%) COVID-19 patients, while 37 (19.68%) influenza A and 27 (18.12%) influenza B patients had acute cardiac injury.
Conclusion: In this study, the illnesses of children with COVID-19 were demonstrated to be less severe than those of paediatric patients with influenza, and COVID-19 patients had milder illness and fewer complications.
Keywords: COVID-19; Children; Clinical features; Influenza; SARS-CoV-2.
. 2021 May 4;21(1):412.
doi: 10.1186/s12879-021-06068-w.
Comparative study of hospitalized children with acute respiratory distress syndrome caused by SARS-CoV-2 and influenza virus
Xinghua Liu[SUP] #[/SUP][SUP] 1 [/SUP], Wei Li[SUP] #[/SUP][SUP] 1 [/SUP], Bo Zhang[SUP] #[/SUP][SUP] 2 [/SUP], Yan Guo[SUP] #[/SUP][SUP] 3 [/SUP], Zhao Hu[SUP] 4 [/SUP], Cao Peng[SUP] 5 [/SUP], Xiao Lei[SUP] 6 [/SUP], Qunying Luo[SUP] 6 [/SUP], Qiong Zhang[SUP] 6 [/SUP], Wei Deng[SUP] 6 [/SUP], Juanjuan Wang[SUP] 7 [/SUP], Jianqiao Tang[SUP] 8 [/SUP], Yunqiao Li[SUP] 9 [/SUP], Jianying Chen[SUP] 10 [/SUP]
Affiliations
- PMID: 33947345
- DOI: 10.1186/s12879-021-06068-w
Abstract
Background: Since the outbreak of coronavirus disease 2019 in December 2019, more than 8 million cases have occurred worldwide as of June 16, 2020. However, it is important to distinguish COVID-19 from other respiratory infectious diseases, such as influenza. Here, we comparatively described the clinical characteristics of children with COVID-19 and paediatric patients with influenza.
Methods: In this retrospective, single-centre study, we reviewed the electronic medical records of 585 paediatric patients with COVID-19 or influenza in Wuhan Children's Hospital, China. Clinical and epidemiological characteristics, laboratory findings, and clinical outcomes were comparatively analysed.
Results: The median ages were 6.96 years (IQR, 2-10.81) for children with confirmed COVID-19, 2.67 years (IQR, 1.03-15.25) for those with influenza A and 3.67 years (IQR, 1.62-5.54) for those with influenza B. Fever was a symptom in 84 (34.7%) COVID-19 cases, 132 (70.21%) influenza A cases and 111 (74.50%) influenza B cases. The median length of stay (LOS) was 11 (8-15) days for paediatric COVID-19 patients, 4 (3-6) days for influenza A patients and 5 (3-6) days for influenza B patients. Twenty-six (13.98%) influenza A patients and 18 (12.59%) influenza B patients presented with decreased white blood cell counts, while 13 (5.33%) COVID-19 patients presented with decreased white blood cell counts. Eight (3.28%) COVID-19 patients, 23 (12.71%) influenza A patients and 21 (14.79%) influenza B patients experienced lymphocytopenia. Acute cardiac injury occurred in 18 (7.29%) COVID-19 patients, while 37 (19.68%) influenza A and 27 (18.12%) influenza B patients had acute cardiac injury.
Conclusion: In this study, the illnesses of children with COVID-19 were demonstrated to be less severe than those of paediatric patients with influenza, and COVID-19 patients had milder illness and fewer complications.
Keywords: COVID-19; Children; Clinical features; Influenza; SARS-CoV-2.