tetano
Editor, Senior Moderator
BMC Infect Dis
. 2023 Dec 6;23(1):856.
doi: 10.1186/s12879-023-08556-7. Decreased NK cell count is a high-risk factor for convulsion in children with COVID-19
Ting Shi[SUP] #[/SUP][SUP] 1 [/SUP], Yuanxi Bian[SUP] #[/SUP][SUP] 1 [/SUP], Jiahui Wu[SUP] #[/SUP][SUP] 1 [/SUP], Xiaohong Li[SUP] #[/SUP][SUP] 1 [/SUP], Jianping Deng[SUP] #[/SUP][SUP] 1 [/SUP], Tao Feng[SUP] #[/SUP][SUP] 1 [/SUP], Linlin Huang[SUP] #[/SUP][SUP] 2 [/SUP], Xiaoxing Kong[SUP] #[/SUP][SUP] 1 [/SUP], Jianmei Tian[SUP] #[/SUP][SUP] 3 [/SUP]
Affiliations
Background: The neurological symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of increasing concern. Convulsions are among the main neurological manifestations reported in children with coronavirus disease-2019 (COVID-19), and cause serious harm to physical and mental health. This study aimed to investigate the risk factors for convulsion in children with COVID-19.
Methods: This prospective study was conducted at the Children's Hospital of Soochow University. In total, 102 COVID-19 patients with convulsion, 172 COVID-19 patients without convulsion, and 50 healthy controls were enrolled in the study. The children's clinical and laboratory data were analyzed to assess the risk factors for convulsion in COVID-19 patients.
Results: Convulsions occurred in 37.2% of children, mostly those aged 1-3 years, who were hospitalized with the Omicron variant. The neutrophil count, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume-to-platelet ratio (MPR) were significantly higher in the convulsion group than those in the non-convulsion and control groups (P < 0.01). However, the counts of lymphocytes, eosinophils, platelets, lymphocyte subsets, CD3[SUP]+[/SUP] T cells, CD4[SUP]+[/SUP] T cells, CD8[SUP]+[/SUP] T cells, and NK cells were lower in the convulsion group than those in the non-convulsion and control groups (P < 0.01). Multivariate regression analysis indicated that NK cell count (OR = 0.081, 95% CI: 0.010-0.652) and a history of febrile seizure (OR = 10.359, 95% CI: 2.115-50.746) were independent risk factors for the appearance of convulsions in COVID-19.
Conclusions: History of febrile seizure and decreased NK cell count were high-risk factors for convulsions in COVID-19 patients.
Keywords: Children; Convulsion; NK cells; Omicron.
. 2023 Dec 6;23(1):856.
doi: 10.1186/s12879-023-08556-7. Decreased NK cell count is a high-risk factor for convulsion in children with COVID-19
Ting Shi[SUP] #[/SUP][SUP] 1 [/SUP], Yuanxi Bian[SUP] #[/SUP][SUP] 1 [/SUP], Jiahui Wu[SUP] #[/SUP][SUP] 1 [/SUP], Xiaohong Li[SUP] #[/SUP][SUP] 1 [/SUP], Jianping Deng[SUP] #[/SUP][SUP] 1 [/SUP], Tao Feng[SUP] #[/SUP][SUP] 1 [/SUP], Linlin Huang[SUP] #[/SUP][SUP] 2 [/SUP], Xiaoxing Kong[SUP] #[/SUP][SUP] 1 [/SUP], Jianmei Tian[SUP] #[/SUP][SUP] 3 [/SUP]
Affiliations
- PMID: 38057734
- DOI: 10.1186/s12879-023-08556-7
Background: The neurological symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of increasing concern. Convulsions are among the main neurological manifestations reported in children with coronavirus disease-2019 (COVID-19), and cause serious harm to physical and mental health. This study aimed to investigate the risk factors for convulsion in children with COVID-19.
Methods: This prospective study was conducted at the Children's Hospital of Soochow University. In total, 102 COVID-19 patients with convulsion, 172 COVID-19 patients without convulsion, and 50 healthy controls were enrolled in the study. The children's clinical and laboratory data were analyzed to assess the risk factors for convulsion in COVID-19 patients.
Results: Convulsions occurred in 37.2% of children, mostly those aged 1-3 years, who were hospitalized with the Omicron variant. The neutrophil count, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume-to-platelet ratio (MPR) were significantly higher in the convulsion group than those in the non-convulsion and control groups (P < 0.01). However, the counts of lymphocytes, eosinophils, platelets, lymphocyte subsets, CD3[SUP]+[/SUP] T cells, CD4[SUP]+[/SUP] T cells, CD8[SUP]+[/SUP] T cells, and NK cells were lower in the convulsion group than those in the non-convulsion and control groups (P < 0.01). Multivariate regression analysis indicated that NK cell count (OR = 0.081, 95% CI: 0.010-0.652) and a history of febrile seizure (OR = 10.359, 95% CI: 2.115-50.746) were independent risk factors for the appearance of convulsions in COVID-19.
Conclusions: History of febrile seizure and decreased NK cell count were high-risk factors for convulsions in COVID-19 patients.
Keywords: Children; Convulsion; NK cells; Omicron.