tetano
Editor, Senior Moderator
BMC Infect Dis
. 2021 Feb 5;21(1):147.
doi: 10.1186/s12879-021-05818-0.
High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study
Huan Cai[SUP] #[/SUP][SUP] 1 [/SUP], Lisha Yang[SUP] #[/SUP][SUP] 1 [/SUP], Yingfeng Lu[SUP] #[/SUP][SUP] 1 [/SUP], Shanyan Zhang[SUP] 1 [/SUP], Chanyuan Ye[SUP] 1 [/SUP], Xiaoli Zhang[SUP] 1 [/SUP], Guodong Yu[SUP] 1 [/SUP], Jueqing Gu[SUP] 1 [/SUP], Jiangshan Lian[SUP] 1 [/SUP], Shaorui Hao[SUP] 1 [/SUP], Jianhua Hu[SUP] 1 [/SUP], Yimin Zhang[SUP] 1 [/SUP], Ciliang Jin[SUP] 1 [/SUP], Jifang Sheng[SUP] 1 [/SUP], Yida Yang[SUP] 2 [/SUP], Hongyu Jia[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019(COVID-19) has spread worldwide. The present study aimed to characterize the clinical features and outcomes of imported COVID-19 patients with high body mass index (BMI) and the independent association of BMI with disease severity.
Methods: In this retrospective cohort study, 455 imported COVID-19 patients were admitted and discharged in Zhejiang province by February 28, 2020. Epidemiological, demographic, clinical, laboratory, radiological, treatment, and outcome data were collected, analyzed and compared between patients with BMI ≥ 24and < 24.
Results: A total of 268 patients had BMI < 24, and 187 patients had BMI ≥ 24. Those with high BMI were mostly men, had a smoking history, fever, cough, and sputum than those with BMI < 24. A large number of patients with BMI ≥ 24 were diagnosed as severe/critical types. Some biochemical indicators were significantly elevated in patients with BMI ≥ 24. Also, acute liver injury was the most common complication in these patients. The median days from illness onset to severe acute respiratory syndrome coronavirus 2 detection, duration of hospitalization, and days from illness onset to discharge were significantly longer in patients with BMI ≥ 24 than those with BMI < 24. High BMI, exposure to Wuhan, any coexisting medical condition, high temperature, C-reactive protein (CRP), and increased lactate dehydrogenase (LDH) were independent risk factors for severe/critical COVID-19. After adjusting for age, sex and above factors, BMI was still independently associated with progression to severe/critical illness (P = 0.0040). Hemoglobin, alanine aminotransferase (ALT), CRP, and serum creatinine (Scr) were independent risk factors associated with high BMI.
Conclusions: Contrasted with the imported COVID-19 patients with BMI < 24, high proportion of COVID-19 patients with BMI ≥ 24 in our study, especially those with elevated CRP and LDH, developed to severe type, with longer hospitalization duration and anti-virus course. Thus, high BMI is a risk factor for the progression and prognosis of imported COVID-19.
Keywords: COVID-19; High BMI; Prognosis; Progression; Risk factor.
. 2021 Feb 5;21(1):147.
doi: 10.1186/s12879-021-05818-0.
High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study
Huan Cai[SUP] #[/SUP][SUP] 1 [/SUP], Lisha Yang[SUP] #[/SUP][SUP] 1 [/SUP], Yingfeng Lu[SUP] #[/SUP][SUP] 1 [/SUP], Shanyan Zhang[SUP] 1 [/SUP], Chanyuan Ye[SUP] 1 [/SUP], Xiaoli Zhang[SUP] 1 [/SUP], Guodong Yu[SUP] 1 [/SUP], Jueqing Gu[SUP] 1 [/SUP], Jiangshan Lian[SUP] 1 [/SUP], Shaorui Hao[SUP] 1 [/SUP], Jianhua Hu[SUP] 1 [/SUP], Yimin Zhang[SUP] 1 [/SUP], Ciliang Jin[SUP] 1 [/SUP], Jifang Sheng[SUP] 1 [/SUP], Yida Yang[SUP] 2 [/SUP], Hongyu Jia[SUP] 3 [/SUP]
Affiliations
- PMID: 33546633
- DOI: 10.1186/s12879-021-05818-0
Abstract
Background: Coronavirus disease 2019(COVID-19) has spread worldwide. The present study aimed to characterize the clinical features and outcomes of imported COVID-19 patients with high body mass index (BMI) and the independent association of BMI with disease severity.
Methods: In this retrospective cohort study, 455 imported COVID-19 patients were admitted and discharged in Zhejiang province by February 28, 2020. Epidemiological, demographic, clinical, laboratory, radiological, treatment, and outcome data were collected, analyzed and compared between patients with BMI ≥ 24and < 24.
Results: A total of 268 patients had BMI < 24, and 187 patients had BMI ≥ 24. Those with high BMI were mostly men, had a smoking history, fever, cough, and sputum than those with BMI < 24. A large number of patients with BMI ≥ 24 were diagnosed as severe/critical types. Some biochemical indicators were significantly elevated in patients with BMI ≥ 24. Also, acute liver injury was the most common complication in these patients. The median days from illness onset to severe acute respiratory syndrome coronavirus 2 detection, duration of hospitalization, and days from illness onset to discharge were significantly longer in patients with BMI ≥ 24 than those with BMI < 24. High BMI, exposure to Wuhan, any coexisting medical condition, high temperature, C-reactive protein (CRP), and increased lactate dehydrogenase (LDH) were independent risk factors for severe/critical COVID-19. After adjusting for age, sex and above factors, BMI was still independently associated with progression to severe/critical illness (P = 0.0040). Hemoglobin, alanine aminotransferase (ALT), CRP, and serum creatinine (Scr) were independent risk factors associated with high BMI.
Conclusions: Contrasted with the imported COVID-19 patients with BMI < 24, high proportion of COVID-19 patients with BMI ≥ 24 in our study, especially those with elevated CRP and LDH, developed to severe type, with longer hospitalization duration and anti-virus course. Thus, high BMI is a risk factor for the progression and prognosis of imported COVID-19.
Keywords: COVID-19; High BMI; Prognosis; Progression; Risk factor.