tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Feb 8;22(1):133.
doi: 10.1186/s12879-022-07065-3.
Persistent, new-onset symptoms and mental health complaints in Long COVID in a Brazilian cohort of non-hospitalized patients
Ricardo Titze-de-Almeida[SUP] 1 2 [/SUP], Thaylise Ramalho da Cunha[SUP] 3 [/SUP], Letícia Dias Dos Santos Silva[SUP] 3 [/SUP], Clarisse Santos Ferreira[SUP] 3 [/SUP], Caroline Pena Silva[SUP] 3 [/SUP], Adriana Pinheiro Ribeiro[SUP] 4 [/SUP], Agenor de Castro Moreira Santos Júnior[SUP] 5 [/SUP], Pedro Renato de Paula Brandão[SUP] 3 [/SUP], Andrezza Paula Brito Silva[SUP] 3 [/SUP], Márcia Cristina Oliveira da Rocha[SUP] 6 [/SUP], Mary-Ann Elvina Xavier[SUP] 3 7 [/SUP], Simoneide Souza Titze-de-Almeida[SUP] 3 7 [/SUP], Helena Eri Shimizu[SUP] 8 [/SUP], Raimundo Nonato Delgado-Rodrigues[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections lead to acute- and chronic Long COVID (LC) symptoms. However, few studies have addressed LC sequelae on brain functions. This study was aimed to examine if acute symptoms of coronavirus disease 2019 (COVID-19) would persist during LC, and if memory problems would be correlated with sleep, depressive mood, or anxious complaints.
Methods: Our work followed a cohort of 236 patients from two public hospitals of the Federal District in mid-western Brazil. Patients' interviews checked for clinical symptoms during acute and LC (5-8 months after real-time reverse transcription polymerase chain reaction, RT-qPCR).
Results: Most cases were non-hospitalized individuals (86.3%) with a median age of 41.2 years. While myalgia (50%), hyposmia (48.3%), and dysgeusia (45.8%) were prevalent symptoms in acute phase, fatigue (21.6%) followed by headache (19.1%) and myalgia (16.1%) commonly occurred during LC. In LC, 39.8% of individuals reported memory complaints, 36.9% felt anxious, 44.9% felt depressed, and 45.8% had sleep problems. Furthermore, memory complaints were associated with sleep problems (adjusted OR 3.206; 95% CI 1.723-6.030) and depressive feelings (adjusted OR 3.981; 95% CI 2.068-7.815).
Conclusions: The SARS-CoV-2 infection leads to persistent symptoms during LC, in which memory problems may be associated with sleep and depressive complaints.
Keywords: Brazil; COVID-19; Depression; Long COVID; Memory; Sleep.
. 2022 Feb 8;22(1):133.
doi: 10.1186/s12879-022-07065-3.
Persistent, new-onset symptoms and mental health complaints in Long COVID in a Brazilian cohort of non-hospitalized patients
Ricardo Titze-de-Almeida[SUP] 1 2 [/SUP], Thaylise Ramalho da Cunha[SUP] 3 [/SUP], Letícia Dias Dos Santos Silva[SUP] 3 [/SUP], Clarisse Santos Ferreira[SUP] 3 [/SUP], Caroline Pena Silva[SUP] 3 [/SUP], Adriana Pinheiro Ribeiro[SUP] 4 [/SUP], Agenor de Castro Moreira Santos Júnior[SUP] 5 [/SUP], Pedro Renato de Paula Brandão[SUP] 3 [/SUP], Andrezza Paula Brito Silva[SUP] 3 [/SUP], Márcia Cristina Oliveira da Rocha[SUP] 6 [/SUP], Mary-Ann Elvina Xavier[SUP] 3 7 [/SUP], Simoneide Souza Titze-de-Almeida[SUP] 3 7 [/SUP], Helena Eri Shimizu[SUP] 8 [/SUP], Raimundo Nonato Delgado-Rodrigues[SUP] 3 [/SUP]
Affiliations
- PMID: 35135496
- DOI: 10.1186/s12879-022-07065-3
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections lead to acute- and chronic Long COVID (LC) symptoms. However, few studies have addressed LC sequelae on brain functions. This study was aimed to examine if acute symptoms of coronavirus disease 2019 (COVID-19) would persist during LC, and if memory problems would be correlated with sleep, depressive mood, or anxious complaints.
Methods: Our work followed a cohort of 236 patients from two public hospitals of the Federal District in mid-western Brazil. Patients' interviews checked for clinical symptoms during acute and LC (5-8 months after real-time reverse transcription polymerase chain reaction, RT-qPCR).
Results: Most cases were non-hospitalized individuals (86.3%) with a median age of 41.2 years. While myalgia (50%), hyposmia (48.3%), and dysgeusia (45.8%) were prevalent symptoms in acute phase, fatigue (21.6%) followed by headache (19.1%) and myalgia (16.1%) commonly occurred during LC. In LC, 39.8% of individuals reported memory complaints, 36.9% felt anxious, 44.9% felt depressed, and 45.8% had sleep problems. Furthermore, memory complaints were associated with sleep problems (adjusted OR 3.206; 95% CI 1.723-6.030) and depressive feelings (adjusted OR 3.981; 95% CI 2.068-7.815).
Conclusions: The SARS-CoV-2 infection leads to persistent symptoms during LC, in which memory problems may be associated with sleep and depressive complaints.
Keywords: Brazil; COVID-19; Depression; Long COVID; Memory; Sleep.
