tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Jan 29;22(1):105.
doi: 10.1186/s12879-022-07075-1.
Preventing COVID-19 outbreaks through surveillance testing in healthcare facilities: a modelling study
Tim Litwin[SUP] 1 2 3 [/SUP], Jens Timmer[SUP] 4 5 6 [/SUP], Mathias Berger[SUP] 7 [/SUP], Andreas Wahl-Kordon[SUP] 8 [/SUP], Matthias J Müller[SUP] 9 10 [/SUP], Clemens Kreutz[SUP] 11 4 6 [/SUP]
Affiliations
Abstract
Background: Surveillance testing within healthcare facilities provides an opportunity to prevent severe outbreaks of coronavirus disease 2019 (COVID-19). However, the quantitative impact of different available surveillance strategies and their potential to decrease the frequency of outbreaks are not well-understood.
Methods: We establish an individual-based model representative of a mental health hospital yielding generalizable results. Attributes and features of this facility were derived from a prototypical hospital, which provides psychiatric, psychosomatic and psychotherapeutic treatment. We estimate the relative reduction of outbreak probability for three test strategies (entry test, once-weekly test and twice-weekly test) relative to a symptom-based baseline strategy. Based on our findings, we propose determinants of successful surveillance measures.
Results: Entry Testing reduced the outbreak probability by 26%, additionally testing once or twice weekly reduced the outbreak probability by 49% or 67% respectively. We found that fast diagnostic test results and adequate compliance of the clinic population are mandatory for conducting effective surveillance. The robustness of these results towards uncertainties is demonstrated via comprehensive sensitivity analyses.
Conclusions: We conclude that active testing in mental health hospitals and similar facilities considerably reduces the number of COVID-19 outbreaks compared to symptom-based surveillance only.
Keywords: Agent-based model; COVID-19; Infectious disease surveillance; Long-term care; Point-of-care testing.
. 2022 Jan 29;22(1):105.
doi: 10.1186/s12879-022-07075-1.
Preventing COVID-19 outbreaks through surveillance testing in healthcare facilities: a modelling study
Tim Litwin[SUP] 1 2 3 [/SUP], Jens Timmer[SUP] 4 5 6 [/SUP], Mathias Berger[SUP] 7 [/SUP], Andreas Wahl-Kordon[SUP] 8 [/SUP], Matthias J Müller[SUP] 9 10 [/SUP], Clemens Kreutz[SUP] 11 4 6 [/SUP]
Affiliations
- PMID: 35093012
- DOI: 10.1186/s12879-022-07075-1
Abstract
Background: Surveillance testing within healthcare facilities provides an opportunity to prevent severe outbreaks of coronavirus disease 2019 (COVID-19). However, the quantitative impact of different available surveillance strategies and their potential to decrease the frequency of outbreaks are not well-understood.
Methods: We establish an individual-based model representative of a mental health hospital yielding generalizable results. Attributes and features of this facility were derived from a prototypical hospital, which provides psychiatric, psychosomatic and psychotherapeutic treatment. We estimate the relative reduction of outbreak probability for three test strategies (entry test, once-weekly test and twice-weekly test) relative to a symptom-based baseline strategy. Based on our findings, we propose determinants of successful surveillance measures.
Results: Entry Testing reduced the outbreak probability by 26%, additionally testing once or twice weekly reduced the outbreak probability by 49% or 67% respectively. We found that fast diagnostic test results and adequate compliance of the clinic population are mandatory for conducting effective surveillance. The robustness of these results towards uncertainties is demonstrated via comprehensive sensitivity analyses.
Conclusions: We conclude that active testing in mental health hospitals and similar facilities considerably reduces the number of COVID-19 outbreaks compared to symptom-based surveillance only.
Keywords: Agent-based model; COVID-19; Infectious disease surveillance; Long-term care; Point-of-care testing.