tetano
Editor, Senior Moderator
BMC Infect Dis
. 2024 May 28;24(1):537.
doi: 10.1186/s12879-024-09420-y. Vertical transmission of SARS-CoV-2 delta-variant in a preterm infant
Muhammad T K Zia[SUP] 1 2 [/SUP], Kishan Kumar[SUP] 1 [/SUP], Edmund La Gamma[SUP] 1 3 [/SUP], Fauzia Shakeel[SUP] 1 [/SUP], Iman Hanna[SUP] 4 [/SUP], Xinhua Lin[SUP] 5 6 [/SUP], Nazeeh Hanna[SUP] 7 8 [/SUP]
Affiliations
Background: As SARS-CoV-2 continues to be relevant and cause illnesses, the effect of emerging virus variants on perinatal health remains to be elucidated. It was demonstrated that vertical transmission of SARS-CoV-2 is a relatively rare event in the original SARS-CoV-2 strain. However, very few reports describe vertical transmission related to the delta-variant.
Case presentation: We report a case of a preterm male neonate born to a mother with positive SARS-CoV-2 and mild respiratory complications. The neonate was born by cesarean section due to fetal distress. The rupture of the amniotic membrane was at delivery. The neonate had expected prematurity-related complications. His nasopharyngeal swabs for RT-PCR were positive from birth till three weeks of age. RT-ddPCR of the Placenta showed a high load of the SARS-CoV-2 virus with subgenomic viral RNA. RNAscope technique demonstrated both the positive strand of the S gene and the orf1ab negative strand. Detection of subgenomic RNA and the orf1ab negative strand indicats active viral replication in the placenta.
Conclusions: Our report demonstrates active viral replication of the SARS-CoV-2 delta-variant in the placenta associated with vertical transmission in a preterm infant.
Keywords: COVID-19; Delta variant; Preterm infant; SARS-CoV-2; Vertical transmission.
. 2024 May 28;24(1):537.
doi: 10.1186/s12879-024-09420-y. Vertical transmission of SARS-CoV-2 delta-variant in a preterm infant
Muhammad T K Zia[SUP] 1 2 [/SUP], Kishan Kumar[SUP] 1 [/SUP], Edmund La Gamma[SUP] 1 3 [/SUP], Fauzia Shakeel[SUP] 1 [/SUP], Iman Hanna[SUP] 4 [/SUP], Xinhua Lin[SUP] 5 6 [/SUP], Nazeeh Hanna[SUP] 7 8 [/SUP]
Affiliations
- PMID: 38807052
- PMCID: PMC11134764
- DOI: 10.1186/s12879-024-09420-y
Background: As SARS-CoV-2 continues to be relevant and cause illnesses, the effect of emerging virus variants on perinatal health remains to be elucidated. It was demonstrated that vertical transmission of SARS-CoV-2 is a relatively rare event in the original SARS-CoV-2 strain. However, very few reports describe vertical transmission related to the delta-variant.
Case presentation: We report a case of a preterm male neonate born to a mother with positive SARS-CoV-2 and mild respiratory complications. The neonate was born by cesarean section due to fetal distress. The rupture of the amniotic membrane was at delivery. The neonate had expected prematurity-related complications. His nasopharyngeal swabs for RT-PCR were positive from birth till three weeks of age. RT-ddPCR of the Placenta showed a high load of the SARS-CoV-2 virus with subgenomic viral RNA. RNAscope technique demonstrated both the positive strand of the S gene and the orf1ab negative strand. Detection of subgenomic RNA and the orf1ab negative strand indicats active viral replication in the placenta.
Conclusions: Our report demonstrates active viral replication of the SARS-CoV-2 delta-variant in the placenta associated with vertical transmission in a preterm infant.
Keywords: COVID-19; Delta variant; Preterm infant; SARS-CoV-2; Vertical transmission.