tetano
Editor, Senior Moderator
BMC Nephrol
. 2024 May 4;25(1):155.
doi: 10.1186/s12882-024-03584-0. Oxidative stress in patients with coronavirus disease and end-stage renal disease: a pilot study
Nam-Seon Beck[SUP] 1 [/SUP], Yeonju Seo[SUP] 2 [/SUP], Taesung Park[SUP] 3 [/SUP], Sang-Sin Jun[SUP] 4 [/SUP], Joung-Il Im[SUP] 5 [/SUP], Sae-Yong Hong[SUP] 6 [/SUP]
Affiliations
Background: Oxidative stress, an imbalance between reactive oxygen species production and antioxidant capacity, increases in patients with coronavirus disease (COVID-19) or renal impairment. We investigated whether combined COVID-19 and end-stage renal disease (ESRD) would increase oxidative stress levels compared to each disease alone.
Methods: Oxidative stress was compared among three groups. Two groups comprised patients with COVID-19 referred to the hospital with or without renal impairment (COVID-ESRD group [n = 18]; COVID group [n = 17]). The third group (ESRD group [n = 18]) comprised patients without COVID-19 on maintenance hemodialysis at a hospital.
Results: The total oxidative stress in the COVID-ESRD group was lower than in the COVID group (p = 0.047). The total antioxidant status was higher in the COVID-ESRD group than in the ESRD (p < 0.001) and COVID (p < 0.001) groups after controlling for covariates. The oxidative stress index was lower in the COVID-ESRD group than in the ESRD (p = 0.001) and COVID (p < 0.001) groups. However, the three oxidative parameters did not differ significantly between the COVID and COVID-ESRD groups.
Conclusions: The role of reactive oxygen species in the pathophysiology of COVID-19 among patients withESRD appears to be non-critical. Therefore, the provision of supplemental antioxidants may not confer a therapeutic advantage, particularly in cases of mild COVID-19 in ESRD patients receiving hemodialysis. Nonetheless, this area merits further research.
Keywords: COVID-19; End-stage renal disease; Hemodialysis; Oxidative stress; Reactive oxygen species.
. 2024 May 4;25(1):155.
doi: 10.1186/s12882-024-03584-0. Oxidative stress in patients with coronavirus disease and end-stage renal disease: a pilot study
Nam-Seon Beck[SUP] 1 [/SUP], Yeonju Seo[SUP] 2 [/SUP], Taesung Park[SUP] 3 [/SUP], Sang-Sin Jun[SUP] 4 [/SUP], Joung-Il Im[SUP] 5 [/SUP], Sae-Yong Hong[SUP] 6 [/SUP]
Affiliations
- PMID: 38702607
- PMCID: PMC11069245
- DOI: 10.1186/s12882-024-03584-0
Background: Oxidative stress, an imbalance between reactive oxygen species production and antioxidant capacity, increases in patients with coronavirus disease (COVID-19) or renal impairment. We investigated whether combined COVID-19 and end-stage renal disease (ESRD) would increase oxidative stress levels compared to each disease alone.
Methods: Oxidative stress was compared among three groups. Two groups comprised patients with COVID-19 referred to the hospital with or without renal impairment (COVID-ESRD group [n = 18]; COVID group [n = 17]). The third group (ESRD group [n = 18]) comprised patients without COVID-19 on maintenance hemodialysis at a hospital.
Results: The total oxidative stress in the COVID-ESRD group was lower than in the COVID group (p = 0.047). The total antioxidant status was higher in the COVID-ESRD group than in the ESRD (p < 0.001) and COVID (p < 0.001) groups after controlling for covariates. The oxidative stress index was lower in the COVID-ESRD group than in the ESRD (p = 0.001) and COVID (p < 0.001) groups. However, the three oxidative parameters did not differ significantly between the COVID and COVID-ESRD groups.
Conclusions: The role of reactive oxygen species in the pathophysiology of COVID-19 among patients withESRD appears to be non-critical. Therefore, the provision of supplemental antioxidants may not confer a therapeutic advantage, particularly in cases of mild COVID-19 in ESRD patients receiving hemodialysis. Nonetheless, this area merits further research.
Keywords: COVID-19; End-stage renal disease; Hemodialysis; Oxidative stress; Reactive oxygen species.