tetano
Editor, Senior Moderator
BMC Pediatr
. 2024 Mar 16;24(1):184.
doi: 10.1186/s12887-024-04665-7. The footprint of SARS-COV-2 infection in neonatal late sepsis
Zahra Jamali[SUP] 1 [/SUP], Najmeh Mohammadpour[SUP] 2 [/SUP], Reza Sinaei[SUP] 3 4 [/SUP], Maedeh Jafari[SUP] 1 [/SUP], Fatemeh Sabzevari[SUP] 5 [/SUP], Mohammad Hasannejad[SUP] 6 [/SUP]
Affiliations
Background: Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging.
Method: In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests.
Result: 145 neonates including 81 girls and 64 boys with a mean age of 12.3 ± 5.9 days and an average hospitalization stay of 23.1 ± 15.4 days were enrolled in the study. While 76.6% of them had negative bacterial culture, 63 patients (43.4%) showed evidence of SARS-COV-2 infection in RT-PCR or serology tests. None of the underlying factors including gender, age, and laboratory investigation had a significant relationship with SARS-COV-2 infection. Similarly, the outcomes of death and length of hospitalization were not different between the two groups with positive and negative SARS-COV-2 RT-PCR (P < 0.05). There was only a significant relationship between radiological changes including reticulonodular pattern, consolidation, pleural effusion, and different types of infiltrations and SARS-COV2 infection.
Conclusion: Considering the widespread of coronavirus disease 2019 (COVID-19) in newborns, it seems logical to investigate the SARS-COV-2 infection in late-sepsis.
Keywords: COVID-19; Late sepsis; Neonate; SARS-COV-2.
. 2024 Mar 16;24(1):184.
doi: 10.1186/s12887-024-04665-7. The footprint of SARS-COV-2 infection in neonatal late sepsis
Zahra Jamali[SUP] 1 [/SUP], Najmeh Mohammadpour[SUP] 2 [/SUP], Reza Sinaei[SUP] 3 4 [/SUP], Maedeh Jafari[SUP] 1 [/SUP], Fatemeh Sabzevari[SUP] 5 [/SUP], Mohammad Hasannejad[SUP] 6 [/SUP]
Affiliations
- PMID: 38491449
- PMCID: PMC10943770
- DOI: 10.1186/s12887-024-04665-7
Background: Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging.
Method: In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests.
Result: 145 neonates including 81 girls and 64 boys with a mean age of 12.3 ± 5.9 days and an average hospitalization stay of 23.1 ± 15.4 days were enrolled in the study. While 76.6% of them had negative bacterial culture, 63 patients (43.4%) showed evidence of SARS-COV-2 infection in RT-PCR or serology tests. None of the underlying factors including gender, age, and laboratory investigation had a significant relationship with SARS-COV-2 infection. Similarly, the outcomes of death and length of hospitalization were not different between the two groups with positive and negative SARS-COV-2 RT-PCR (P < 0.05). There was only a significant relationship between radiological changes including reticulonodular pattern, consolidation, pleural effusion, and different types of infiltrations and SARS-COV2 infection.
Conclusion: Considering the widespread of coronavirus disease 2019 (COVID-19) in newborns, it seems logical to investigate the SARS-COV-2 infection in late-sepsis.
Keywords: COVID-19; Late sepsis; Neonate; SARS-COV-2.