tetano
Editor, Senior Moderator
BMC Public Health
. 2024 May 26;24(1):1401.
doi: 10.1186/s12889-024-18922-y. Factors associated with SARS-CoV-2 vaccine hesitancy after stroke: a cross-sectional study
Peng Hu[SUP] #[/SUP][SUP] 1 [/SUP], Ying-Hai Zhu[SUP] #[/SUP][SUP] 1 [/SUP], Chuan-Chuan Bai[SUP] 1 2 [/SUP], Wei Wang[SUP] 3 [/SUP], Duo Li[SUP] 4 [/SUP], Lei Cao[SUP] 5 [/SUP], Yan-Qing Huang[SUP] 6 [/SUP], Tian Heng[SUP] 1 [/SUP], Xiao-Han Zhou[SUP] 1 [/SUP], Tao Liu[SUP] 1 [/SUP], Ya-Xi Luo[SUP] 7 [/SUP], Xiu-Qing Yao[SUP] 8 9 [/SUP]
Affiliations
Background: The vaccination status of post-stroke patients, who are at high risk of severe outcomes from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a significant concern, yet it remains unclear. We aimed to explore the vaccination status, factors associated with vaccine hesitancy, and adverse effects after vaccination among post-stroke patients.
Methods: This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.
Results: Of the total 710 post-stroke patients included in the study, 430 (60.6%) had completed the recommended full-3 dose SARS-CoV-2 vaccination, with 176 (24.8%) remaining unvaccinated. The most common reasons for vaccine hesitancy were concerns about vaccine side effects (41.5%) and impaired mobility (33.9%). Logistic regression identified advanced age (aOR = 1.97, 95%CI: 1.36-2.85, P = 0.001), lower Barthel Index score (aOR = 0.88, 95%CI: 0.82-0.93, P = 0.018), higher Modified Rankin Scale score (aOR = 1.85, 95%CI: 1.32-2.56, P = 0.004), and poorer usual activity level of EuroQol 5-Dimension (aOR = 2.82, 95%CI: 1.51-5.28, P = 0.001) as independent risk factors for vaccine hesitancy. Approximately 14.8% reported minor adverse reactions, mainly pain at the injection site.
Conclusion: We found that post-stroke patients have insufficient SARS-CoV-2 vaccination rates, with key risk factors for vaccine hesitancy including concerns about side effects, advanced age, and functional impairments. No severe adverse reactions were observed among the vaccinated population.
Keywords: SARS-CoV-2; Stroke; Vaccination status; Vaccine hesitancy.
. 2024 May 26;24(1):1401.
doi: 10.1186/s12889-024-18922-y. Factors associated with SARS-CoV-2 vaccine hesitancy after stroke: a cross-sectional study
Peng Hu[SUP] #[/SUP][SUP] 1 [/SUP], Ying-Hai Zhu[SUP] #[/SUP][SUP] 1 [/SUP], Chuan-Chuan Bai[SUP] 1 2 [/SUP], Wei Wang[SUP] 3 [/SUP], Duo Li[SUP] 4 [/SUP], Lei Cao[SUP] 5 [/SUP], Yan-Qing Huang[SUP] 6 [/SUP], Tian Heng[SUP] 1 [/SUP], Xiao-Han Zhou[SUP] 1 [/SUP], Tao Liu[SUP] 1 [/SUP], Ya-Xi Luo[SUP] 7 [/SUP], Xiu-Qing Yao[SUP] 8 9 [/SUP]
Affiliations
- PMID: 38797861
- DOI: 10.1186/s12889-024-18922-y
Background: The vaccination status of post-stroke patients, who are at high risk of severe outcomes from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a significant concern, yet it remains unclear. We aimed to explore the vaccination status, factors associated with vaccine hesitancy, and adverse effects after vaccination among post-stroke patients.
Methods: This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.
Results: Of the total 710 post-stroke patients included in the study, 430 (60.6%) had completed the recommended full-3 dose SARS-CoV-2 vaccination, with 176 (24.8%) remaining unvaccinated. The most common reasons for vaccine hesitancy were concerns about vaccine side effects (41.5%) and impaired mobility (33.9%). Logistic regression identified advanced age (aOR = 1.97, 95%CI: 1.36-2.85, P = 0.001), lower Barthel Index score (aOR = 0.88, 95%CI: 0.82-0.93, P = 0.018), higher Modified Rankin Scale score (aOR = 1.85, 95%CI: 1.32-2.56, P = 0.004), and poorer usual activity level of EuroQol 5-Dimension (aOR = 2.82, 95%CI: 1.51-5.28, P = 0.001) as independent risk factors for vaccine hesitancy. Approximately 14.8% reported minor adverse reactions, mainly pain at the injection site.
Conclusion: We found that post-stroke patients have insufficient SARS-CoV-2 vaccination rates, with key risk factors for vaccine hesitancy including concerns about side effects, advanced age, and functional impairments. No severe adverse reactions were observed among the vaccinated population.
Keywords: SARS-CoV-2; Stroke; Vaccination status; Vaccine hesitancy.