tetano
Editor, Senior Moderator
BMC Vet Res
. 2022 Mar 22;18(1):111.
doi: 10.1186/s12917-022-03191-x.
Pulmonary fibrosis in a dog as a sequela of infection with Severe Acute Respiratory Syndrome Coronavirus 2? A case report
Barbara Colitti[SUP] 1 [/SUP], Luca Manassero[SUP] 2 [/SUP], Elena Colombino[SUP] 2 [/SUP], Erica Ilaria Ferraris[SUP] 2 [/SUP], Roberta Caccamo[SUP] 2 [/SUP], Luigi Bertolotti[SUP] 2 [/SUP], Alessio Bortolami[SUP] 3 [/SUP], Francesco Bonfante[SUP] 3 [/SUP], Valentina Papa[SUP] 4 [/SUP], Giovanna Cenacchi[SUP] 4 [/SUP], Fiorella Calabrese[SUP] 5 [/SUP], Elena Bozzetta[SUP] 6 [/SUP], Katia Varello[SUP] 6 [/SUP], Maria Teresa Capucchio[SUP] #[/SUP][SUP] 2 [/SUP], Sergio Rosati[SUP] #[/SUP][SUP] 2 [/SUP]
Affiliations
Abstract
Background: Interstitial lung disease is a heterogeneous group of conditions characterized by severe radiographic changes and clinicopathological findings. However, in the vast majority of cases, the cause remains unknown.
Case description: In the present study, we reported the clinical case of a 3 years old female Bull Terrier presented in October 2020 to the Advanced Diagnostic Imaging Department of the Turin Veterinary Teaching Hospital with a progressive pulmonary illness characterized by dyspnea, exercise intolerance, and a diffuse and severe pulmonary interstitial pattern at imaging investigations. Considering the clinical findings, the dog was included in a serological survey for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in companion animals, showing positive results. Due to the further clinical worsening, the owners opted for euthanasia. At necroscopy, dog showed severe and chronic bronchopneumonia compatible with a Canine Idiopathic Pulmonary Fibrosis and with serological features linked to a SARS-CoV-2 infection.
Conclusions: The comparison of these lesions with those reported in humans affected by Coronavirus Disease 2019 (COVID-19) supports the hypothesis that these findings may be attributable to the post-acute sequelae of SARS-CoV-2 infection in a dog with breed predisposition to Canine Idiopathic Pulmonary Fibrosis (CIPF), although direct evidence of SARS-CoV-2 by molecular or antigenic approaches remained unsolved.
Keywords: COVID-19; Diagnosis; Dog; Pneumonia; SARS-CoV-2.
. 2022 Mar 22;18(1):111.
doi: 10.1186/s12917-022-03191-x.
Pulmonary fibrosis in a dog as a sequela of infection with Severe Acute Respiratory Syndrome Coronavirus 2? A case report
Barbara Colitti[SUP] 1 [/SUP], Luca Manassero[SUP] 2 [/SUP], Elena Colombino[SUP] 2 [/SUP], Erica Ilaria Ferraris[SUP] 2 [/SUP], Roberta Caccamo[SUP] 2 [/SUP], Luigi Bertolotti[SUP] 2 [/SUP], Alessio Bortolami[SUP] 3 [/SUP], Francesco Bonfante[SUP] 3 [/SUP], Valentina Papa[SUP] 4 [/SUP], Giovanna Cenacchi[SUP] 4 [/SUP], Fiorella Calabrese[SUP] 5 [/SUP], Elena Bozzetta[SUP] 6 [/SUP], Katia Varello[SUP] 6 [/SUP], Maria Teresa Capucchio[SUP] #[/SUP][SUP] 2 [/SUP], Sergio Rosati[SUP] #[/SUP][SUP] 2 [/SUP]
Affiliations
- PMID: 35317791
- DOI: 10.1186/s12917-022-03191-x
Abstract
Background: Interstitial lung disease is a heterogeneous group of conditions characterized by severe radiographic changes and clinicopathological findings. However, in the vast majority of cases, the cause remains unknown.
Case description: In the present study, we reported the clinical case of a 3 years old female Bull Terrier presented in October 2020 to the Advanced Diagnostic Imaging Department of the Turin Veterinary Teaching Hospital with a progressive pulmonary illness characterized by dyspnea, exercise intolerance, and a diffuse and severe pulmonary interstitial pattern at imaging investigations. Considering the clinical findings, the dog was included in a serological survey for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in companion animals, showing positive results. Due to the further clinical worsening, the owners opted for euthanasia. At necroscopy, dog showed severe and chronic bronchopneumonia compatible with a Canine Idiopathic Pulmonary Fibrosis and with serological features linked to a SARS-CoV-2 infection.
Conclusions: The comparison of these lesions with those reported in humans affected by Coronavirus Disease 2019 (COVID-19) supports the hypothesis that these findings may be attributable to the post-acute sequelae of SARS-CoV-2 infection in a dog with breed predisposition to Canine Idiopathic Pulmonary Fibrosis (CIPF), although direct evidence of SARS-CoV-2 by molecular or antigenic approaches remained unsolved.
Keywords: COVID-19; Diagnosis; Dog; Pneumonia; SARS-CoV-2.
