tetano
Editor, Senior Moderator
BMJ Open Respir Res
. 2025 Feb 17;12(1):e002694.
doi: 10.1136/bmjresp-2024-002694. COVID-19 and risk of long-term mortality in COPD: a nationwide population-based cohort study
Hyun Lee[SUP] 1 [/SUP], Sang Hyuk Kim[SUP] 2 3 [/SUP], Cho Yun Jeong[SUP] 4 [/SUP], Jee-Eun Chung[SUP] 5 [/SUP], Youlim Kim[SUP] 6 [/SUP], Kyung Hoon Min[SUP] 2 [/SUP], Kwang Ha Yoo[SUP] 6 [/SUP], Jong Seung Kim[SUP] 7 8 9 [/SUP], Ji-Yong Moon[SUP] 10 [/SUP]
Affiliations
Background: Chronic obstructive pulmonary disease (COPD) is a risk factor for severe COVID-19. However, mortality after COVID-19 recovery in this population remains unclear.
Methods: We retrospectively enrolled individuals with COPD from the Korean National Health Insurance database. We compared the mortality rate in individuals with COPD who recovered from COVID-19 between 8 October 2020 and 31 December 2021 (COVID-19 cohort, n=2499) with that in 1:1 propensity score-matched controls (n=2499). The study population was followed until either death or 30 September 2022, whichever came first.
Results: The COVID-19 cohort had a 4.8% mortality rate vs 2.7% in matched controls during a median follow-up of 319 days (IQR, 293-422 days), including 14 days of recovery time. The COVID-19 cohort had a higher risk of death than matched controls (adjusted HR (aHR)=1.81, 95% CI=1.35 to 2.45). The risk of mortality was notably higher in individuals with severe COVID-19 (aHR=5.05, 95% CI=3.65 to 6.97), especially during the first 180 days of recovery (highest during the first 30 days (aHR=20.25, 95% CI=7.79 to 52.64)). Non-severe COVID-19 does not increase the risk of mortality compared with controls (aHR=0.85, 95% CI=0.57 to 1.28).
Conclusion: Individuals with COPD recovering from COVID-19 showed an increased risk of long-term mortality, particularly within the first 180 days post-recovery, especially those who experienced severe COVID-19.
Keywords: COVID-19; Pulmonary Disease, Chronic Obstructive; Respiratory Infection; Viral infection.
. 2025 Feb 17;12(1):e002694.
doi: 10.1136/bmjresp-2024-002694. COVID-19 and risk of long-term mortality in COPD: a nationwide population-based cohort study
Hyun Lee[SUP] 1 [/SUP], Sang Hyuk Kim[SUP] 2 3 [/SUP], Cho Yun Jeong[SUP] 4 [/SUP], Jee-Eun Chung[SUP] 5 [/SUP], Youlim Kim[SUP] 6 [/SUP], Kyung Hoon Min[SUP] 2 [/SUP], Kwang Ha Yoo[SUP] 6 [/SUP], Jong Seung Kim[SUP] 7 8 9 [/SUP], Ji-Yong Moon[SUP] 10 [/SUP]
Affiliations
- PMID: 39961706
- DOI: 10.1136/bmjresp-2024-002694
Background: Chronic obstructive pulmonary disease (COPD) is a risk factor for severe COVID-19. However, mortality after COVID-19 recovery in this population remains unclear.
Methods: We retrospectively enrolled individuals with COPD from the Korean National Health Insurance database. We compared the mortality rate in individuals with COPD who recovered from COVID-19 between 8 October 2020 and 31 December 2021 (COVID-19 cohort, n=2499) with that in 1:1 propensity score-matched controls (n=2499). The study population was followed until either death or 30 September 2022, whichever came first.
Results: The COVID-19 cohort had a 4.8% mortality rate vs 2.7% in matched controls during a median follow-up of 319 days (IQR, 293-422 days), including 14 days of recovery time. The COVID-19 cohort had a higher risk of death than matched controls (adjusted HR (aHR)=1.81, 95% CI=1.35 to 2.45). The risk of mortality was notably higher in individuals with severe COVID-19 (aHR=5.05, 95% CI=3.65 to 6.97), especially during the first 180 days of recovery (highest during the first 30 days (aHR=20.25, 95% CI=7.79 to 52.64)). Non-severe COVID-19 does not increase the risk of mortality compared with controls (aHR=0.85, 95% CI=0.57 to 1.28).
Conclusion: Individuals with COPD recovering from COVID-19 showed an increased risk of long-term mortality, particularly within the first 180 days post-recovery, especially those who experienced severe COVID-19.
Keywords: COVID-19; Pulmonary Disease, Chronic Obstructive; Respiratory Infection; Viral infection.