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Editor, Senior Moderator
BMJ Open. 2016 Aug 1;6(8):e010625. doi: 10.1136/bmjopen-2015-010625.
[h=1]Uptake of childhood influenza vaccine from 2012-2013 to 2014-2015 in the UK and the implications for high-risk children: a retrospective observational cohort study.[/h] Rajaram S[SUP]1[/SUP], Steffey A[SUP]2[/SUP], Blak B[SUP]3[/SUP], Hickman M[SUP]4[/SUP], Christensen H[SUP]4[/SUP], Caspard H[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] To evaluate changes in influenza vaccination rates in healthy and at-risk children following the implementation of the UK's childhood influenza immunisation programme.
[h=4]DESIGN:[/h] Observational cohort study before and after initiation of the UK's childhood influenza immunisation programme over three influenza seasons (2012-2013, 2013-2014 and 2014-2015) using data from the Clinical Practice Research Datalink (CPRD).
[h=4]SETTING:[/h] More than 500 primary care practices in the UK.
[h=4]POPULATION:[/h] All individuals aged 2-17 years on 1 September, with at least 12 months of medical history documented in CPRD were retained in the analysis.
[h=4]INTERVENTION:[/h] Starting in 2013-2014, all children aged 2 and 3 years were offered influenza vaccination through general practice, and primary school-aged children were offered influenza vaccination in selected counties in England (described as pilot regions). The vaccination programme was extended to all children aged 4 years in England in 2014-2015.
[h=4]MAIN OUTCOME MEASURE:[/h] Cumulative vaccination rate from 1 September to 28 February of the next calendar year as assessed by a time-to-event statistical model (vaccination uptake). Age group, sex, region and type of high-risk medical condition were assessed as predictors.
[h=4]RESULTS:[/h] Vaccination uptake increased considerably from 2012-2013 to 2013-2014 in targeted children aged 2-3 years, both in children with a high-risk medical condition (from 40.7% to 61.1%) and those without (from 1.0% to 43.0%). Vaccination rates increased also, though less markedly, in older children. In 2014-2015, vaccination rates remained higher than 40% in healthy children aged 2-3 years, although they decreased slightly from 2013-2014 (from 43.0% to 41.8%). Vaccination rates in older healthy children continued to increase, driven primarily by an increase in children aged 4 years to 31.3% in 2014-2015.
[h=4]CONCLUSIONS:[/h] The introduction of a universal childhood vaccination policy in the UK increased vaccination rates for targeted children, including those with high-risk conditions.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
[h=4]KEYWORDS:[/h] High-risk; Influenza; Paediatric; Uptake; Vaccination
PMID: 27481618 DOI: 10.1136/bmjopen-2015-010625
[PubMed - in process] Free full text
[h=1]Uptake of childhood influenza vaccine from 2012-2013 to 2014-2015 in the UK and the implications for high-risk children: a retrospective observational cohort study.[/h] Rajaram S[SUP]1[/SUP], Steffey A[SUP]2[/SUP], Blak B[SUP]3[/SUP], Hickman M[SUP]4[/SUP], Christensen H[SUP]4[/SUP], Caspard H[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] To evaluate changes in influenza vaccination rates in healthy and at-risk children following the implementation of the UK's childhood influenza immunisation programme.
[h=4]DESIGN:[/h] Observational cohort study before and after initiation of the UK's childhood influenza immunisation programme over three influenza seasons (2012-2013, 2013-2014 and 2014-2015) using data from the Clinical Practice Research Datalink (CPRD).
[h=4]SETTING:[/h] More than 500 primary care practices in the UK.
[h=4]POPULATION:[/h] All individuals aged 2-17 years on 1 September, with at least 12 months of medical history documented in CPRD were retained in the analysis.
[h=4]INTERVENTION:[/h] Starting in 2013-2014, all children aged 2 and 3 years were offered influenza vaccination through general practice, and primary school-aged children were offered influenza vaccination in selected counties in England (described as pilot regions). The vaccination programme was extended to all children aged 4 years in England in 2014-2015.
[h=4]MAIN OUTCOME MEASURE:[/h] Cumulative vaccination rate from 1 September to 28 February of the next calendar year as assessed by a time-to-event statistical model (vaccination uptake). Age group, sex, region and type of high-risk medical condition were assessed as predictors.
[h=4]RESULTS:[/h] Vaccination uptake increased considerably from 2012-2013 to 2013-2014 in targeted children aged 2-3 years, both in children with a high-risk medical condition (from 40.7% to 61.1%) and those without (from 1.0% to 43.0%). Vaccination rates increased also, though less markedly, in older children. In 2014-2015, vaccination rates remained higher than 40% in healthy children aged 2-3 years, although they decreased slightly from 2013-2014 (from 43.0% to 41.8%). Vaccination rates in older healthy children continued to increase, driven primarily by an increase in children aged 4 years to 31.3% in 2014-2015.
[h=4]CONCLUSIONS:[/h] The introduction of a universal childhood vaccination policy in the UK increased vaccination rates for targeted children, including those with high-risk conditions.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
[h=4]KEYWORDS:[/h] High-risk; Influenza; Paediatric; Uptake; Vaccination
PMID: 27481618 DOI: 10.1136/bmjopen-2015-010625
[PubMed - in process] Free full text