tetano
Editor, Senior Moderator
Br J Clin Pharmacol
. 2020 Nov 27.
doi: 10.1111/bcp.14677. Online ahead of print.
Clinical studies assessing the efficacy, effectiveness, and safety of remdesivir in management of COVID-19: a scoping review
Juan Pimentel[SUP] 1 2 3 [/SUP], Cassandra Laurie[SUP] 4 [/SUP], Anne Cockcroft[SUP] 1 5 [/SUP], Neil Andersson[SUP] 1 5 [/SUP]
Affiliations
Abstract
Aim: Remdesivir is one of the repurposed drugs under investigation to treat patients with COVID-19. Clinicians and decision-makers need a summary of the most recent evidence. This scoping review maps the evidence on the efficacy, effectiveness, and safety of remdesivir for patients with COVID-19, up to September 14[SUP]th[/SUP] , 2020.
Methods: Our scoping review searched Pubmed, Embase (Ovid), Scopus, and 17 primary trial registries for empirical publications or active registered clinical trials for data on the efficacy, effectiveness, or safety of remdesivir for COVID-19 or SARS-CoV-2. We conducted a narrative synthesis of the included publications.
Results: 17 empirical studies and 23 clinical trial registrations (n=40) accumulated 46,508 participants. We found four published randomised controlled trials accumulating 2,293 patients. Two trials reported shorter median recovery time and better clinical status among patients who received remdesivir compared with the control groups. Observational studies report an association between remdesivir treatment and decreased mortality, as well as increased survival. The most common adverse reaction was hepatic impairment, although the trials reported a similar proportion of adverse events in the intervention and control groups.
Conclusion: Remdesivir might shorten the time to clinical improvement among hospitalized adults with severe COVID-19. Trial data report a similar proportion of adverse events in treated and control groups. The results of the 23 registered active trials, including more than 30,000 participants, will shed light on the efficacy and safety of the antiviral. The findings of the remaining clinical trials expected to report results in 2020 will allow a quantitative synthesis of available evidence.
Keywords: GS 5734; covid 19; remdesivir; scoping review; severe acute respiratory syndrome coronavirus 2.
. 2020 Nov 27.
doi: 10.1111/bcp.14677. Online ahead of print.
Clinical studies assessing the efficacy, effectiveness, and safety of remdesivir in management of COVID-19: a scoping review
Juan Pimentel[SUP] 1 2 3 [/SUP], Cassandra Laurie[SUP] 4 [/SUP], Anne Cockcroft[SUP] 1 5 [/SUP], Neil Andersson[SUP] 1 5 [/SUP]
Affiliations
- PMID: 33245577
- DOI: 10.1111/bcp.14677
Abstract
Aim: Remdesivir is one of the repurposed drugs under investigation to treat patients with COVID-19. Clinicians and decision-makers need a summary of the most recent evidence. This scoping review maps the evidence on the efficacy, effectiveness, and safety of remdesivir for patients with COVID-19, up to September 14[SUP]th[/SUP] , 2020.
Methods: Our scoping review searched Pubmed, Embase (Ovid), Scopus, and 17 primary trial registries for empirical publications or active registered clinical trials for data on the efficacy, effectiveness, or safety of remdesivir for COVID-19 or SARS-CoV-2. We conducted a narrative synthesis of the included publications.
Results: 17 empirical studies and 23 clinical trial registrations (n=40) accumulated 46,508 participants. We found four published randomised controlled trials accumulating 2,293 patients. Two trials reported shorter median recovery time and better clinical status among patients who received remdesivir compared with the control groups. Observational studies report an association between remdesivir treatment and decreased mortality, as well as increased survival. The most common adverse reaction was hepatic impairment, although the trials reported a similar proportion of adverse events in the intervention and control groups.
Conclusion: Remdesivir might shorten the time to clinical improvement among hospitalized adults with severe COVID-19. Trial data report a similar proportion of adverse events in treated and control groups. The results of the 23 registered active trials, including more than 30,000 participants, will shed light on the efficacy and safety of the antiviral. The findings of the remaining clinical trials expected to report results in 2020 will allow a quantitative synthesis of available evidence.
Keywords: GS 5734; covid 19; remdesivir; scoping review; severe acute respiratory syndrome coronavirus 2.