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Br J Haematol . Clinical characteristics, management and outcome of Covid-19-associated immune thrombocytopenia. A French multicenter series

tetano

Editor, Senior Moderator
Br J Haematol


. 2020 Jul 17.
doi: 10.1111/bjh.17024. Online ahead of print.
Clinical characteristics, management and outcome of Covid-19-associated immune thrombocytopenia. A French multicenter series


Matthieu Mah?vas[SUP] 1 [/SUP], Guillaume Moulis[SUP] 2 3 4 [/SUP], Emmanuel Andres[SUP] 5 [/SUP], Etienne Riviere[SUP] 6 7 [/SUP], Margaux Garzaro[SUP] 8 [/SUP], Etienne Crickx[SUP] 1 [/SUP], Vivien Guillotin[SUP] 5 [/SUP], Marion Malphettes[SUP] 8 [/SUP], Lionel Galicier[SUP] 8 [/SUP], Nicolas Noel[SUP] 9 [/SUP], Luc Darnige[SUP] 10 [/SUP], Louis Terriou[SUP] 11 [/SUP], Claire Guerveno[SUP] 12 [/SUP], Mateo Sanchis-Borja[SUP] 13 [/SUP], Thomas Moulinet[SUP] 14 [/SUP], Benoit Meunier[SUP] 15 [/SUP], Mikael Ebbo[SUP] 15 [/SUP], Marc Michel[SUP] 1 [/SUP], Bertrand Godeau[SUP] 1 [/SUP]



Affiliations

Abstract

The causes of secondary immune thrombocytopenia (ITP), which account for approximately 18 to 20% of all adult ITP cases, include some viral infections (Cines et al, 2009; Moulis et al, 2014). Indeed, ITP can be triggered by or associated with many viruses including hepatitis C virus, human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus and others like severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) (Boyer Chammard et al, 2017; Tanaka et al, 2003; Yang et al, 2005; Cines et al, 2009). Among the suspected mechanisms, antibodies directed against virus glycoproteins may cross-react with platelet surface integrins like GPIIb/IIIa or GPIb-IX-V (Assinger, 2014).
 
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