tetano
Editor, Senior Moderator
Br J Haematol
. 2023 May 25.
doi: 10.1111/bjh.18876. Online ahead of print. Influenza A (H1N1) virus induced long-term remission in a refractory acute myeloid leukaemia
Liangshun You[SUP] 1 2 3 [/SUP], Yi Liu[SUP] 1 [/SUP], Nianci Chen[SUP] 1 [/SUP], Li Zhu[SUP] 1 [/SUP], Gaixiang Xu[SUP] 1 2 3 [/SUP], Zuopo Lv[SUP] 1 [/SUP], Yile Zhou[SUP] 1 2 3 [/SUP], Chenying Li[SUP] 1 2 3 [/SUP], Hongyan Tong[SUP] 1 2 3 [/SUP], Jie Jin[SUP] 1 2 3 [/SUP], Haitao Meng[SUP] 1 2 3 [/SUP]
Affiliations
There have been reports of haematological cancer patients achieving spontaneous remission after being infected with the influenza A or SARS-COV-2 virus. Here, we present the first case of long-term complete remission (CR) induced by influenza A (IAV, H1N1 subtype) in a refractory AML patient and have functionally validated this finding in two different animal disease models. We observed a significant increase in the proportion of helper T cells in the patient after IAV infection. The levels of cytokines, including IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ and TNF-α, were higher in IAV-infected patients compared with control groups. These findings indicate that the anti-tumour effects induced by IAV are closely related to the modification of the immune response. Our study provides new evidence of the anti-tumour effects of IAV from a clinical practice perspective.
Keywords: acute myeloid leukaemia (AML); immunity; influenza A virus.
. 2023 May 25.
doi: 10.1111/bjh.18876. Online ahead of print. Influenza A (H1N1) virus induced long-term remission in a refractory acute myeloid leukaemia
Liangshun You[SUP] 1 2 3 [/SUP], Yi Liu[SUP] 1 [/SUP], Nianci Chen[SUP] 1 [/SUP], Li Zhu[SUP] 1 [/SUP], Gaixiang Xu[SUP] 1 2 3 [/SUP], Zuopo Lv[SUP] 1 [/SUP], Yile Zhou[SUP] 1 2 3 [/SUP], Chenying Li[SUP] 1 2 3 [/SUP], Hongyan Tong[SUP] 1 2 3 [/SUP], Jie Jin[SUP] 1 2 3 [/SUP], Haitao Meng[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 37230766
- DOI: 10.1111/bjh.18876
There have been reports of haematological cancer patients achieving spontaneous remission after being infected with the influenza A or SARS-COV-2 virus. Here, we present the first case of long-term complete remission (CR) induced by influenza A (IAV, H1N1 subtype) in a refractory AML patient and have functionally validated this finding in two different animal disease models. We observed a significant increase in the proportion of helper T cells in the patient after IAV infection. The levels of cytokines, including IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ and TNF-α, were higher in IAV-infected patients compared with control groups. These findings indicate that the anti-tumour effects induced by IAV are closely related to the modification of the immune response. Our study provides new evidence of the anti-tumour effects of IAV from a clinical practice perspective.
Keywords: acute myeloid leukaemia (AML); immunity; influenza A virus.