tetano
Editor, Senior Moderator
Br J Haematol
. 2020 Jun 4.
doi: 10.1111/bjh.16916. Online ahead of print.
Terminal Complement Inhibition Dampens the Inflammation During COVID-19
Austin G Kulasekararaj[SUP] 1 2 3 [/SUP], Ioanna Lazana[SUP] 1 [/SUP], Joanna Large[SUP] 1 [/SUP], Kristina Posadas[SUP] 2 [/SUP], Helen Eagleton[SUP] 4 [/SUP], John Lord Villajin[SUP] 2 [/SUP], Mark Zuckerman[SUP] 5 [/SUP], Shreyans Gandhi[SUP] 1 2 [/SUP], Judith Cw Marsh[SUP] 1 3 [/SUP]
Affiliations
Abstract
Emerging evidence suggests that activation of the complement system is critical in the pathogenesis of the novel coronavirus, SARS-CoV-2, the causative agent of COVID-19 related lung injury. Inhibition of the terminal complement pathway by targeting complement protein 5 (C5) may be an effective therapeutic intervention in CoV-mediated disease.[SUP]1[/SUP] Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired hematopoietic stem cell (HSC) disease characterized by intravascular haemolysis, increased thromboembolic risk and bone marrow failure.[SUP]2[/SUP].
. 2020 Jun 4.
doi: 10.1111/bjh.16916. Online ahead of print.
Terminal Complement Inhibition Dampens the Inflammation During COVID-19
Austin G Kulasekararaj[SUP] 1 2 3 [/SUP], Ioanna Lazana[SUP] 1 [/SUP], Joanna Large[SUP] 1 [/SUP], Kristina Posadas[SUP] 2 [/SUP], Helen Eagleton[SUP] 4 [/SUP], John Lord Villajin[SUP] 2 [/SUP], Mark Zuckerman[SUP] 5 [/SUP], Shreyans Gandhi[SUP] 1 2 [/SUP], Judith Cw Marsh[SUP] 1 3 [/SUP]
Affiliations
- PMID: 32495372
- DOI: 10.1111/bjh.16916
Abstract
Emerging evidence suggests that activation of the complement system is critical in the pathogenesis of the novel coronavirus, SARS-CoV-2, the causative agent of COVID-19 related lung injury. Inhibition of the terminal complement pathway by targeting complement protein 5 (C5) may be an effective therapeutic intervention in CoV-mediated disease.[SUP]1[/SUP] Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired hematopoietic stem cell (HSC) disease characterized by intravascular haemolysis, increased thromboembolic risk and bone marrow failure.[SUP]2[/SUP].