tetano
Editor, Senior Moderator
Br J Pharmacol
. 2022 Nov 17.
doi: 10.1111/bph.15987. Online ahead of print.
Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2
Wern Hann Ng[SUP] 1 2 3 [/SUP], Patrick Chun Hean Tang[SUP] 1 2 3 [/SUP], Suresh Mahalingam[SUP] 1 2 3 [/SUP], Xiang Liu[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis-associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide, resulting in an urgent need for effective therapeutic interventions. Repurposing immunosuppressive drugs that target cytokines with immunomodulatory properties is a promising approach to counteract SARS-CoV-2-induced ARDS at the infective and post-infective stages. In this minireview, we examine drugs targeting IL-1β, IL-4/IL-13, IL-6 and TNF-α tested in COVID-19 patients.
Keywords: COVID-19; Cytokine storm; SARS-CoV-2; immunosuppressive drugs.
. 2022 Nov 17.
doi: 10.1111/bph.15987. Online ahead of print.
Repurposing of drugs targeting the cytokine storm induced by SARS-CoV-2
Wern Hann Ng[SUP] 1 2 3 [/SUP], Patrick Chun Hean Tang[SUP] 1 2 3 [/SUP], Suresh Mahalingam[SUP] 1 2 3 [/SUP], Xiang Liu[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 36394425
- DOI: 10.1111/bph.15987
Abstract
A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis-associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide, resulting in an urgent need for effective therapeutic interventions. Repurposing immunosuppressive drugs that target cytokines with immunomodulatory properties is a promising approach to counteract SARS-CoV-2-induced ARDS at the infective and post-infective stages. In this minireview, we examine drugs targeting IL-1β, IL-4/IL-13, IL-6 and TNF-α tested in COVID-19 patients.
Keywords: COVID-19; Cytokine storm; SARS-CoV-2; immunosuppressive drugs.