tetano
Editor, Senior Moderator
Brain Res Bull
. 2022 Jun 27;S0361-9230(22)00157-5.
doi: 10.1016/j.brainresbull.2022.06.014. Online ahead of print.
Nervous system manifestations related to COVID-19 and their possible mechanisms
Zhen Xie[SUP] 1 [/SUP], Hao Hui[SUP] 2 [/SUP], Zhihan Zhao[SUP] 3 [/SUP], Wenjin Yu[SUP] 4 [/SUP], Rui Wu[SUP] 4 [/SUP], Yanzhao Zhu[SUP] 3 [/SUP], Yuan Song[SUP] 3 [/SUP], Bingqing Cao[SUP] 5 [/SUP], Wenzhen Shi[SUP] 6 [/SUP], Di Zhao[SUP] 4 [/SUP], Yunsong Zhao[SUP] 4 [/SUP], Junchao Lv[SUP] 4 [/SUP], Qian Yao[SUP] 3 [/SUP], Yan Duan[SUP] 3 [/SUP], Jingwen Li[SUP] 7 [/SUP], Haijun Zhang[SUP] 4 [/SUP], Linfu Zhou[SUP] 3 [/SUP], Xiaotian Wang[SUP] 8 [/SUP], Ye Tian[SUP] 6 [/SUP], Gang Zhao[SUP] 3 [/SUP]
Affiliations
Abstract
In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.
Keywords: CNS; COVID-19; Neuroinvasion; Neurology; Neuropsychiatry; PNS; SARS-CoV-2.
. 2022 Jun 27;S0361-9230(22)00157-5.
doi: 10.1016/j.brainresbull.2022.06.014. Online ahead of print.
Nervous system manifestations related to COVID-19 and their possible mechanisms
Zhen Xie[SUP] 1 [/SUP], Hao Hui[SUP] 2 [/SUP], Zhihan Zhao[SUP] 3 [/SUP], Wenjin Yu[SUP] 4 [/SUP], Rui Wu[SUP] 4 [/SUP], Yanzhao Zhu[SUP] 3 [/SUP], Yuan Song[SUP] 3 [/SUP], Bingqing Cao[SUP] 5 [/SUP], Wenzhen Shi[SUP] 6 [/SUP], Di Zhao[SUP] 4 [/SUP], Yunsong Zhao[SUP] 4 [/SUP], Junchao Lv[SUP] 4 [/SUP], Qian Yao[SUP] 3 [/SUP], Yan Duan[SUP] 3 [/SUP], Jingwen Li[SUP] 7 [/SUP], Haijun Zhang[SUP] 4 [/SUP], Linfu Zhou[SUP] 3 [/SUP], Xiaotian Wang[SUP] 8 [/SUP], Ye Tian[SUP] 6 [/SUP], Gang Zhao[SUP] 3 [/SUP]
Affiliations
- PMID: 35772604
- DOI: 10.1016/j.brainresbull.2022.06.014
Abstract
In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.
Keywords: CNS; COVID-19; Neuroinvasion; Neurology; Neuropsychiatry; PNS; SARS-CoV-2.