tetano
Editor, Senior Moderator
Curr Opin Virol. 2018 Nov 26;34:1-9. doi: 10.1016/j.coviro.2018.11.005. [Epub ahead of print]
[h=1]Broadly protective influenza vaccines: design and production platforms.[/h] Elbahesh H[SUP]1[/SUP], Saletti G[SUP]1[/SUP], Gerlach T[SUP]1[/SUP], Rimmelzwaan GF[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in ∼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging influenza viruses. To address the need for rapid efficacious vaccines that could mitigate the impact of seasonal and future pandemics, multiple platforms are under development and/or investigation. What is clear is that any universal vaccine must provide long-lasting cross-protective immunity that can induce both B and T cell responses. This review will explore some of the universal influenza vaccine platforms in the contexts of their ability to induce long-lasting and cross-protective T cell immunity.
PMID: 30497050 DOI: 10.1016/j.coviro.2018.11.005
[h=1]Broadly protective influenza vaccines: design and production platforms.[/h] Elbahesh H[SUP]1[/SUP], Saletti G[SUP]1[/SUP], Gerlach T[SUP]1[/SUP], Rimmelzwaan GF[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Effective vaccines are the cornerstone of our defenses against acute influenza virus infections that result in ∼500 000 annual deaths worldwide. For decades, an on-going concerted effort has been to develop a universal influenza vaccine to combat the looming threat of potentially pandemic emerging and re-emerging influenza viruses. To address the need for rapid efficacious vaccines that could mitigate the impact of seasonal and future pandemics, multiple platforms are under development and/or investigation. What is clear is that any universal vaccine must provide long-lasting cross-protective immunity that can induce both B and T cell responses. This review will explore some of the universal influenza vaccine platforms in the contexts of their ability to induce long-lasting and cross-protective T cell immunity.
PMID: 30497050 DOI: 10.1016/j.coviro.2018.11.005