tetano
Editor, Senior Moderator
Bull Exp Biol Med
. 2022 Jan 10;1-4.
doi: 10.1007/s10517-022-05393-7. Online ahead of print.
Mechanisms of the Effects of Short-Term Inhalations of Xe and O [SUB]2[/SUB] Gas Mixture in the Rehabilitation of Post-COVID Ventilation Failure
V V Udut[SUP] 1 2 [/SUP], S A Naumov[SUP] 3 [/SUP], E V Udut[SUP] 3 4 [/SUP], S S Naumov[SUP] 4 [/SUP], D N Evtushenko[SUP] 5 [/SUP], O N Chumakova[SUP] 3 [/SUP], G N Zyuz'kov[SUP] 3 [/SUP]
Affiliations
Abstract
The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O[SUB]2[/SUB] gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O[SUB]2[/SUB] gas mixture relieved manifestations of ventilation insufficiency and increased SpO[SUB]2[/SUB] and pneumatization of the terminal parts of the lungs.
Keywords: dipalmitoylphosphatidylcholine; molecular electrostatic potential; post-COVID complications; pulmonary surfactant; Хе.
. 2022 Jan 10;1-4.
doi: 10.1007/s10517-022-05393-7. Online ahead of print.
Mechanisms of the Effects of Short-Term Inhalations of Xe and O [SUB]2[/SUB] Gas Mixture in the Rehabilitation of Post-COVID Ventilation Failure
V V Udut[SUP] 1 2 [/SUP], S A Naumov[SUP] 3 [/SUP], E V Udut[SUP] 3 4 [/SUP], S S Naumov[SUP] 4 [/SUP], D N Evtushenko[SUP] 5 [/SUP], O N Chumakova[SUP] 3 [/SUP], G N Zyuz'kov[SUP] 3 [/SUP]
Affiliations
- PMID: 35001305
- PMCID: PMC8743161
- DOI: 10.1007/s10517-022-05393-7
Abstract
The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O[SUB]2[/SUB] gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O[SUB]2[/SUB] gas mixture relieved manifestations of ventilation insufficiency and increased SpO[SUB]2[/SUB] and pneumatization of the terminal parts of the lungs.
Keywords: dipalmitoylphosphatidylcholine; molecular electrostatic potential; post-COVID complications; pulmonary surfactant; Хе.