tetano
Editor, Senior Moderator
Bull Math Biol
. 2021 May 26;83(7):79.
doi: 10.1007/s11538-021-00909-0.
Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques
Ericka Mochan[SUP] 1 [/SUP], T J Sego[SUP] 2 [/SUP], Lauren Gaona[SUP] 3 [/SUP], Emmaline Rial[SUP] 4 [/SUP], G Bard Ermentrout[SUP] 4 [/SUP]
Affiliations
Abstract
The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis. The virus is primarily associated with flu-like symptoms but can also lead to severe pathologies and death. We here present an ordinary differential equation model of the intrahost immune response to SARS-CoV-2 infection, fitted to experimental data gleaned from rhesus macaques. The model is calibrated to data from a nonlethal infection, but the model can replicate behavior from various lethal scenarios as well. We evaluate the sensitivity of the model to biologically relevant parameters governing the strength and efficacy of the immune response. We also simulate the effect of both anti-inflammatory and antiviral drugs on the host immune response and demonstrate the ability of the model to lessen the severity of a formerly lethal infection with the addition of the appropriately calibrated drug. Our model emphasizes the importance of tight control of the innate immune response for host survival and viral clearance.
Keywords: Innate immunity; Mathematical modeling of COVID-19.
. 2021 May 26;83(7):79.
doi: 10.1007/s11538-021-00909-0.
Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques
Ericka Mochan[SUP] 1 [/SUP], T J Sego[SUP] 2 [/SUP], Lauren Gaona[SUP] 3 [/SUP], Emmaline Rial[SUP] 4 [/SUP], G Bard Ermentrout[SUP] 4 [/SUP]
Affiliations
- PMID: 34037874
- DOI: 10.1007/s11538-021-00909-0
Abstract
The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis. The virus is primarily associated with flu-like symptoms but can also lead to severe pathologies and death. We here present an ordinary differential equation model of the intrahost immune response to SARS-CoV-2 infection, fitted to experimental data gleaned from rhesus macaques. The model is calibrated to data from a nonlethal infection, but the model can replicate behavior from various lethal scenarios as well. We evaluate the sensitivity of the model to biologically relevant parameters governing the strength and efficacy of the immune response. We also simulate the effect of both anti-inflammatory and antiviral drugs on the host immune response and demonstrate the ability of the model to lessen the severity of a formerly lethal infection with the addition of the appropriately calibrated drug. Our model emphasizes the importance of tight control of the innate immune response for host survival and viral clearance.
Keywords: Innate immunity; Mathematical modeling of COVID-19.