tetano
Editor, Senior Moderator
Vaccine. 2016 Jan 2. pii: S0264-410X(15)01863-0. doi: 10.1016/j.vaccine.2015.12.052. [Epub ahead of print]
[h=1]Burden of four vaccine preventable diseases in older adults.[/h] Kristensen M[SUP]1[/SUP], van Lier A[SUP]2[/SUP], Eilers R[SUP]3[/SUP], McDonald SA[SUP]4[/SUP], Opstelten W[SUP]5[/SUP], van der Maas N[SUP]6[/SUP], van der Hoek W[SUP]7[/SUP], Kretzschmar ME[SUP]8[/SUP], Nielen MM[SUP]9[/SUP], de Melker HE[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Implementation of additional targeted vaccinations to prevent infectious diseases in the elderly is under discussion in different countries. When considering the added value of such preventive measures, insight in the current disease burden will assist in prioritization. The aim of this study was to estimate the disease burden in adults aged 50 years and over for influenza, pertussis, pneumococcal disease and herpes zoster.
[h=4]METHODS:[/h] The average annual disease burden for these four diseases in the Netherlands was calculated for the period 2010-2013 using the disability-adjusted life years (DALY) measure. Disease models and parameters were obtained from previous research. Where possible we adapted these models specifically for older adults and applied age-specific parameters derived from literature. The disease burden based on these adapted models and parameters was compared with the disease burden based on the general population models.
[h=4]RESULTS:[/h] The estimated average annual disease burden was from high to low: pneumococcal disease (37,223 DALYs/year), influenza (7941 DALYs/year), herpes zoster (942 DALYs/year), and pertussis (812 DALYs/year). The adaptation of models and parameters specifically for the elderly resulted in a higher disease burden compared to the use of general population models.
[h=4]CONCLUSIONS:[/h] Among the elderly, the disease burden in the period 2010-2013 was highest for pneumococcal disease, mostly because of the high mortality, followed by influenza, while disease burden of herpes zoster and pertussis was relatively low and consisted mostly of years lived with disability. Better information on the course of infectious diseases and long-term consequences would enable more accurate disease burden estimations in older adults and the elderly.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Disability-adjusted life years (DALY); Disease burden; Elderly; Herpes zoster; Influenza; Pertussis; Pneumococcal disease
PMID: 26752065 [PubMed - as supplied by publisher]
[h=1]Burden of four vaccine preventable diseases in older adults.[/h] Kristensen M[SUP]1[/SUP], van Lier A[SUP]2[/SUP], Eilers R[SUP]3[/SUP], McDonald SA[SUP]4[/SUP], Opstelten W[SUP]5[/SUP], van der Maas N[SUP]6[/SUP], van der Hoek W[SUP]7[/SUP], Kretzschmar ME[SUP]8[/SUP], Nielen MM[SUP]9[/SUP], de Melker HE[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Implementation of additional targeted vaccinations to prevent infectious diseases in the elderly is under discussion in different countries. When considering the added value of such preventive measures, insight in the current disease burden will assist in prioritization. The aim of this study was to estimate the disease burden in adults aged 50 years and over for influenza, pertussis, pneumococcal disease and herpes zoster.
[h=4]METHODS:[/h] The average annual disease burden for these four diseases in the Netherlands was calculated for the period 2010-2013 using the disability-adjusted life years (DALY) measure. Disease models and parameters were obtained from previous research. Where possible we adapted these models specifically for older adults and applied age-specific parameters derived from literature. The disease burden based on these adapted models and parameters was compared with the disease burden based on the general population models.
[h=4]RESULTS:[/h] The estimated average annual disease burden was from high to low: pneumococcal disease (37,223 DALYs/year), influenza (7941 DALYs/year), herpes zoster (942 DALYs/year), and pertussis (812 DALYs/year). The adaptation of models and parameters specifically for the elderly resulted in a higher disease burden compared to the use of general population models.
[h=4]CONCLUSIONS:[/h] Among the elderly, the disease burden in the period 2010-2013 was highest for pneumococcal disease, mostly because of the high mortality, followed by influenza, while disease burden of herpes zoster and pertussis was relatively low and consisted mostly of years lived with disability. Better information on the course of infectious diseases and long-term consequences would enable more accurate disease burden estimations in older adults and the elderly.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Disability-adjusted life years (DALY); Disease burden; Elderly; Herpes zoster; Influenza; Pertussis; Pneumococcal disease
PMID: 26752065 [PubMed - as supplied by publisher]