tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2015 Dec 28. pii: AAC.02055-15. [Epub ahead of print]
[h=1]C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection.[/h] Zhao D[SUP]1[/SUP], Fukuyama S[SUP]1[/SUP], Sakai-Tagawa Y[SUP]2[/SUP], Takashita E[SUP]3[/SUP], Shoemaker JE[SUP]1[/SUP], Kawaoka Y[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] New strategies to develop novel broad-spectrum anti-viral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo, and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26711748 [PubMed - as supplied by publisher]
[h=1]C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection.[/h] Zhao D[SUP]1[/SUP], Fukuyama S[SUP]1[/SUP], Sakai-Tagawa Y[SUP]2[/SUP], Takashita E[SUP]3[/SUP], Shoemaker JE[SUP]1[/SUP], Kawaoka Y[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] New strategies to develop novel broad-spectrum anti-viral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo, and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26711748 [PubMed - as supplied by publisher]