tetano
Editor, Senior Moderator
Can Commun Dis Rep
. 2023 Apr 1;49(4):103-112.
doi: 10.14745/ccdr.v49i04a03. Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada
Daniel Farrar[SUP] 1 [/SUP], Charlotte Moore Hepburn[SUP] 2 3 [/SUP], Olivier Drouin[SUP] 4 5 [/SUP], Tala El Tal[SUP] 6 [/SUP], Marie-Paule Morin[SUP] 7 [/SUP], Roberta Berard[SUP] 8 [/SUP], Melanie King[SUP] 9 [/SUP], Melanie Laffin Thibodeau[SUP] 9 [/SUP], Krista Baerg[SUP] 10 11 [/SUP], Guillaume Beaudoin-Bussières[SUP] 12 [/SUP], Camille Beaufils[SUP] 7 [/SUP], Terri-Lyn Bennett[SUP] 13 [/SUP], Susanne Benseler[SUP] 14 15 [/SUP], Kevin Chan[SUP] 16 17 18 [/SUP], Claude Cyr[SUP] 19 [/SUP], Nagib Dahdah[SUP] 20 [/SUP], Elizabeth Donner[SUP] 16 21 [/SUP], Joanne Embree[SUP] 22 23 [/SUP], Catherine Farrell[SUP] 24 [/SUP], Andrés Finzi[SUP] 12 [/SUP], Sarah Forgie[SUP] 25 26 [/SUP], Ryan Giroux[SUP] 27 [/SUP], Kristopher Kang[SUP] 28 [/SUP], Bianca Lang[SUP] 29 [/SUP], Ronald Laxer[SUP] 6 16 [/SUP], Brian McCrindle[SUP] 30 [/SUP], Julia Orkin[SUP] 2 31 [/SUP], Jesse Papenburg[SUP] 32 33 [/SUP], Catherine Pound[SUP] 34 [/SUP], Victoria Price[SUP] 35 [/SUP], Jean-Phillippe Proulx-Gauthier[SUP] 36 [/SUP], Rupeena Purewal[SUP] 10 37 [/SUP], Manish Sadarangani[SUP] 28 38 [/SUP], Marina Salvadori[SUP] 13 [/SUP], Roseline Thibeault[SUP] 39 [/SUP], Karina Top[SUP] 40 [/SUP], Isabelle Viel-Thériault[SUP] 39 [/SUP], Elie Haddad[SUP] 7 [/SUP], Rosie Scuccimarri[SUP] 41 [/SUP], Rae Yeung[SUP] 6 42 43 [/SUP], Fatima Kakkar[SUP] 44 [/SUP], Shaun Morris[SUP] 1 16 45 46 [/SUP]
Affiliations
Background: Direct comparisons of paediatric hospitalizations for acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. We describe the absolute and relative hospital burden of acute paediatric COVID-19 and MIS-C in Canada.
Methods: This national prospective study was conducted via the Canadian Paediatric Surveillance Program from March 2020-May 2021. Children younger than 18 years old and hospitalized for acute COVID-19 or MIS-C were included in the analysis. Outcomes included supplemental oxygen (low-flow oxygen or high-flow nasal cannula), ventilation (non-invasive or conventional mechanical), vasopressors, paediatric intensive care unit (PICU) admission, or death. Adjusted risk differences (aRD) and 95% confidence intervals (CI) were calculated to identify factors associated with each diagnosis.
Results: Overall, we identified 330 children hospitalized for acute COVID-19 (including five deaths) and 208 hospitalized for MIS-C (including zero deaths); PICU admission was required for 49.5% of MIS-C hospitalizations versus 18.2% of acute COVID-19 hospitalizations (aRD 20.3; 95% CI, 9.9-30.8). Resource use differed by age, with children younger than one year hospitalized more often for acute COVID-19 (aRD 43.4% versus MIS-C; 95% CI, 37.7-49.1) and more children 5-11 years hospitalized for MIS-C (aRD 38.9% vs. acute COVID-19; 95% CI, 31.0-46.9).
Conclusion: While there were more hospitalizations and deaths from acute paediatric COVID-19, MIS-C cases were more severe, requiring more intensive care and vasopressor support. Our findings suggest that both acute COVID-19 and MIS-C should be considered when assessing the overall burden of severe acute respiratory syndrome coronavirus 2 in hospitalized children.
Keywords: COVID-19; MIS-C; SARS-CoV-2; hospitalizations; intensive care; multisystem inflammatory syndrome in children; paediatrics; resource use; surveillance.
. 2023 Apr 1;49(4):103-112.
doi: 10.14745/ccdr.v49i04a03. Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada
Daniel Farrar[SUP] 1 [/SUP], Charlotte Moore Hepburn[SUP] 2 3 [/SUP], Olivier Drouin[SUP] 4 5 [/SUP], Tala El Tal[SUP] 6 [/SUP], Marie-Paule Morin[SUP] 7 [/SUP], Roberta Berard[SUP] 8 [/SUP], Melanie King[SUP] 9 [/SUP], Melanie Laffin Thibodeau[SUP] 9 [/SUP], Krista Baerg[SUP] 10 11 [/SUP], Guillaume Beaudoin-Bussières[SUP] 12 [/SUP], Camille Beaufils[SUP] 7 [/SUP], Terri-Lyn Bennett[SUP] 13 [/SUP], Susanne Benseler[SUP] 14 15 [/SUP], Kevin Chan[SUP] 16 17 18 [/SUP], Claude Cyr[SUP] 19 [/SUP], Nagib Dahdah[SUP] 20 [/SUP], Elizabeth Donner[SUP] 16 21 [/SUP], Joanne Embree[SUP] 22 23 [/SUP], Catherine Farrell[SUP] 24 [/SUP], Andrés Finzi[SUP] 12 [/SUP], Sarah Forgie[SUP] 25 26 [/SUP], Ryan Giroux[SUP] 27 [/SUP], Kristopher Kang[SUP] 28 [/SUP], Bianca Lang[SUP] 29 [/SUP], Ronald Laxer[SUP] 6 16 [/SUP], Brian McCrindle[SUP] 30 [/SUP], Julia Orkin[SUP] 2 31 [/SUP], Jesse Papenburg[SUP] 32 33 [/SUP], Catherine Pound[SUP] 34 [/SUP], Victoria Price[SUP] 35 [/SUP], Jean-Phillippe Proulx-Gauthier[SUP] 36 [/SUP], Rupeena Purewal[SUP] 10 37 [/SUP], Manish Sadarangani[SUP] 28 38 [/SUP], Marina Salvadori[SUP] 13 [/SUP], Roseline Thibeault[SUP] 39 [/SUP], Karina Top[SUP] 40 [/SUP], Isabelle Viel-Thériault[SUP] 39 [/SUP], Elie Haddad[SUP] 7 [/SUP], Rosie Scuccimarri[SUP] 41 [/SUP], Rae Yeung[SUP] 6 42 43 [/SUP], Fatima Kakkar[SUP] 44 [/SUP], Shaun Morris[SUP] 1 16 45 46 [/SUP]
Affiliations
- PMID: 38356877
- PMCID: PMC10866613
- DOI: 10.14745/ccdr.v49i04a03
Background: Direct comparisons of paediatric hospitalizations for acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. We describe the absolute and relative hospital burden of acute paediatric COVID-19 and MIS-C in Canada.
Methods: This national prospective study was conducted via the Canadian Paediatric Surveillance Program from March 2020-May 2021. Children younger than 18 years old and hospitalized for acute COVID-19 or MIS-C were included in the analysis. Outcomes included supplemental oxygen (low-flow oxygen or high-flow nasal cannula), ventilation (non-invasive or conventional mechanical), vasopressors, paediatric intensive care unit (PICU) admission, or death. Adjusted risk differences (aRD) and 95% confidence intervals (CI) were calculated to identify factors associated with each diagnosis.
Results: Overall, we identified 330 children hospitalized for acute COVID-19 (including five deaths) and 208 hospitalized for MIS-C (including zero deaths); PICU admission was required for 49.5% of MIS-C hospitalizations versus 18.2% of acute COVID-19 hospitalizations (aRD 20.3; 95% CI, 9.9-30.8). Resource use differed by age, with children younger than one year hospitalized more often for acute COVID-19 (aRD 43.4% versus MIS-C; 95% CI, 37.7-49.1) and more children 5-11 years hospitalized for MIS-C (aRD 38.9% vs. acute COVID-19; 95% CI, 31.0-46.9).
Conclusion: While there were more hospitalizations and deaths from acute paediatric COVID-19, MIS-C cases were more severe, requiring more intensive care and vasopressor support. Our findings suggest that both acute COVID-19 and MIS-C should be considered when assessing the overall burden of severe acute respiratory syndrome coronavirus 2 in hospitalized children.
Keywords: COVID-19; MIS-C; SARS-CoV-2; hospitalizations; intensive care; multisystem inflammatory syndrome in children; paediatrics; resource use; surveillance.