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Virulence. 2012 Jul 1;3(4). [Epub ahead of print]
Can high-pathogenic avian influenza viruses with novel hemagglutinin serotypes other than H5 or H7 emerge?
Stech J, Mettenleiter TC.
Source
Institute of Molecular Biology; Friedrich-Loeffler-Institut; Federal Research Institute for Animal Health; Greifswald, Germany.
PMID:
22722239
[PubMed - as supplied by publisher]
Re: Can high-pathogenic avian influenza viruses with novel hemagglutinin serotypes other than H5 or H7 emerge?
H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chicken.
".......These results suggest that an HPAIV with a subtype other than H5 or H7 would only emerge under conditions where the HA gene could acquire a polybasic cleavage site and the other viral genes carry additional virulence determinants."
