tetano
Editor, Senior Moderator
Can J Infect Dis Med Microbiol
. 2022 Apr 9;2022:1553266.
doi: 10.1155/2022/1553266. eCollection 2022.
Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo
Patrick Bisimwa Ntagereka[SUP] 1 [/SUP], Rodrigue Ayagirwe Basengere[SUP] 1 [/SUP], Tshass Chasinga Baharanyi[SUP] 2 3 [/SUP], Théophile Mitima Kashosi[SUP] 1 2 [/SUP], Jean-Paul Chikwanine Buhendwa[SUP] 2 4 [/SUP], Parvine Basimane Bisimwa[SUP] 2 4 [/SUP], Aline Byabene Kusinza[SUP] 2 4 [/SUP], Yannick Mugumaarhahama[SUP] 1 [/SUP], Dieudonne Wasso Shukuru[SUP] 1 [/SUP], Simon Baenyi Patrick[SUP] 1 [/SUP], Ronald Tonui[SUP] 5 [/SUP], Ahadi Bwihangane Birindwa[SUP] 1 [/SUP], Denis Mukwege[SUP] 2 6 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with clinical manifestation cases that are almost similar to those of common respiratory viral infections. This study determined the prevalence of SARS-CoV-2 and other acute respiratory viruses among patients with flu-like symptoms in Bukavu city, Democratic Republic of Congo. We screened 1352 individuals with flu-like illnesses seeking treatment in 10 health facilities. Nasopharyngeal swab specimens were collected to detect SARS-CoV-2 using real-time reverse transcription-polymerase chain reaction (RT-PCR), and 10 common respiratory viruses were detected by multiplex reverse transcription-polymerase chain reaction assay. Overall, 13.9% (188/1352) of patients were confirmed positive for SARS-CoV-2. Influenza A 5.6% (56/1352) and Influenza B 0.9% (12/1352) were the most common respiratory viruses detected. Overall, more than two cases of the other acute respiratory viruses were detected. Frequently observed symptoms associated with SARS-CoV-2 positivity were shivering (47.8%; OR = 1.8; CI: 0.88-1.35), cough (89.6%; OR = 6.5, CI: 2.16-28.2), and myalgia and dizziness (59.7%; OR = 2.7; CI: 1.36-5.85). Moreover, coinfection was observed in 12 (11.5%) specimens. SARS-CoV-2 and influenza A were the most cooccurring infections, accounting for 33.3% of all positive cases. This study demonstrates cases of COVID-19 infections cooccurring with other acute respiratory infections in Bukavu city during the ongoing outbreak of COVID-19. Therefore, testing for respiratory viruses should be performed in all patients with flu-like symptoms for effective surveillance of the transmission patterns in the COVID-19 affected areas for optimal treatment and effective disease management.
. 2022 Apr 9;2022:1553266.
doi: 10.1155/2022/1553266. eCollection 2022.
Molecular Evidence of Coinfection with Acute Respiratory Viruses and High Prevalence of SARS-CoV-2 among Patients Presenting Flu-Like Illness in Bukavu City, Democratic Republic of Congo
Patrick Bisimwa Ntagereka[SUP] 1 [/SUP], Rodrigue Ayagirwe Basengere[SUP] 1 [/SUP], Tshass Chasinga Baharanyi[SUP] 2 3 [/SUP], Théophile Mitima Kashosi[SUP] 1 2 [/SUP], Jean-Paul Chikwanine Buhendwa[SUP] 2 4 [/SUP], Parvine Basimane Bisimwa[SUP] 2 4 [/SUP], Aline Byabene Kusinza[SUP] 2 4 [/SUP], Yannick Mugumaarhahama[SUP] 1 [/SUP], Dieudonne Wasso Shukuru[SUP] 1 [/SUP], Simon Baenyi Patrick[SUP] 1 [/SUP], Ronald Tonui[SUP] 5 [/SUP], Ahadi Bwihangane Birindwa[SUP] 1 [/SUP], Denis Mukwege[SUP] 2 6 [/SUP]
Affiliations
- PMID: 35411212
- PMCID: PMC8994514
- DOI: 10.1155/2022/1553266
Abstract
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with clinical manifestation cases that are almost similar to those of common respiratory viral infections. This study determined the prevalence of SARS-CoV-2 and other acute respiratory viruses among patients with flu-like symptoms in Bukavu city, Democratic Republic of Congo. We screened 1352 individuals with flu-like illnesses seeking treatment in 10 health facilities. Nasopharyngeal swab specimens were collected to detect SARS-CoV-2 using real-time reverse transcription-polymerase chain reaction (RT-PCR), and 10 common respiratory viruses were detected by multiplex reverse transcription-polymerase chain reaction assay. Overall, 13.9% (188/1352) of patients were confirmed positive for SARS-CoV-2. Influenza A 5.6% (56/1352) and Influenza B 0.9% (12/1352) were the most common respiratory viruses detected. Overall, more than two cases of the other acute respiratory viruses were detected. Frequently observed symptoms associated with SARS-CoV-2 positivity were shivering (47.8%; OR = 1.8; CI: 0.88-1.35), cough (89.6%; OR = 6.5, CI: 2.16-28.2), and myalgia and dizziness (59.7%; OR = 2.7; CI: 1.36-5.85). Moreover, coinfection was observed in 12 (11.5%) specimens. SARS-CoV-2 and influenza A were the most cooccurring infections, accounting for 33.3% of all positive cases. This study demonstrates cases of COVID-19 infections cooccurring with other acute respiratory infections in Bukavu city during the ongoing outbreak of COVID-19. Therefore, testing for respiratory viruses should be performed in all patients with flu-like symptoms for effective surveillance of the transmission patterns in the COVID-19 affected areas for optimal treatment and effective disease management.