tetano
Editor, Senior Moderator
Cardiol Res
. 2021 Aug;12(4):258-264.
doi: 10.14740/cr1276. Epub 2021 Jun 9.
Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients
Rana Al-Zakhari[SUP] 1 [/SUP], Muhammed Atere[SUP] 1 [/SUP], William Lim[SUP] 1 [/SUP], Mustafa Abdulrahman[SUP] 2 [/SUP], Shahnaz Akhtar[SUP] 3 [/SUP], Nicholas Sheets[SUP] 4 [/SUP], Thomas Joyce[SUP] 4 [/SUP], Veronika Stefanishina[SUP] 4 [/SUP], Edmund Appiah-Kubi[SUP] 5 [/SUP], Philipa Owusu-Antwi[SUP] 5 [/SUP], Jay Nfonoyim[SUP] 1 [/SUP], Richard Grodman[SUP] 6 [/SUP], Francesco Rotatori[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has risen to the level of a global pandemic. Growing evidence has proven the cardiac involvement in SARS-CoV-2 infection. This study aims to evaluate the ability of cardiovascular complications determined by elevated troponin and electrocardiogram findings (e.g., corrected QT interval (QTc)) in predicting the severity of SARS-CoV-2 infection among hospitalized patients.
Methods: This is a retrospective review of medical records of 800 patients, admitted to Richmond University Medical Center in Staten Island, NY, and tested positive for SARS-CoV-2 between March 1, 2020 and July 31, 2020. A total of 339 patients met the study inclusion and exclusion criteria and were included in statistical analysis.
Results: Elevated serum troponin levels on admission statistically correlated with mortality in SARS-CoV-2 patients. Prolonged QTc was shown to have an independent statistically significant association with mortality among patients hospitalized with SARS-CoV-2.
Conclusions: Growing concern for cardiovascular sequelae of coronavirus disease 2019 (COVID-19) has prompted many researchers to investigate the role of cardiovascular complications in mortality due to SARS-CoV-2. Obtaining a simple electrocardiogram for hospitalized patients with COVID-19 could provide an independent prognostic tool and prompt more coordinated treatment strategies to prevent mortality among patients hospitalized with COVID-19.
Keywords: Cardiovascular; Coronavirus; Electrocardiogram; Mortality; QTc; QTc prolongation; SARS-CoV-2; Troponin.
. 2021 Aug;12(4):258-264.
doi: 10.14740/cr1276. Epub 2021 Jun 9.
Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients
Rana Al-Zakhari[SUP] 1 [/SUP], Muhammed Atere[SUP] 1 [/SUP], William Lim[SUP] 1 [/SUP], Mustafa Abdulrahman[SUP] 2 [/SUP], Shahnaz Akhtar[SUP] 3 [/SUP], Nicholas Sheets[SUP] 4 [/SUP], Thomas Joyce[SUP] 4 [/SUP], Veronika Stefanishina[SUP] 4 [/SUP], Edmund Appiah-Kubi[SUP] 5 [/SUP], Philipa Owusu-Antwi[SUP] 5 [/SUP], Jay Nfonoyim[SUP] 1 [/SUP], Richard Grodman[SUP] 6 [/SUP], Francesco Rotatori[SUP] 6 [/SUP]
Affiliations
- PMID: 34349868
- PMCID: PMC8297043
- DOI: 10.14740/cr1276
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has risen to the level of a global pandemic. Growing evidence has proven the cardiac involvement in SARS-CoV-2 infection. This study aims to evaluate the ability of cardiovascular complications determined by elevated troponin and electrocardiogram findings (e.g., corrected QT interval (QTc)) in predicting the severity of SARS-CoV-2 infection among hospitalized patients.
Methods: This is a retrospective review of medical records of 800 patients, admitted to Richmond University Medical Center in Staten Island, NY, and tested positive for SARS-CoV-2 between March 1, 2020 and July 31, 2020. A total of 339 patients met the study inclusion and exclusion criteria and were included in statistical analysis.
Results: Elevated serum troponin levels on admission statistically correlated with mortality in SARS-CoV-2 patients. Prolonged QTc was shown to have an independent statistically significant association with mortality among patients hospitalized with SARS-CoV-2.
Conclusions: Growing concern for cardiovascular sequelae of coronavirus disease 2019 (COVID-19) has prompted many researchers to investigate the role of cardiovascular complications in mortality due to SARS-CoV-2. Obtaining a simple electrocardiogram for hospitalized patients with COVID-19 could provide an independent prognostic tool and prompt more coordinated treatment strategies to prevent mortality among patients hospitalized with COVID-19.
Keywords: Cardiovascular; Coronavirus; Electrocardiogram; Mortality; QTc; QTc prolongation; SARS-CoV-2; Troponin.