tetano
Editor, Senior Moderator
Adv Healthc Mater. 2018 Dec 14:e1800953. doi: 10.1002/adhm.201800953. [Epub ahead of print]
[h=1]Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus.[/h] Lim JW[SUP]1[/SUP], Na W[SUP]2[/SUP], Kim HO[SUP]2[/SUP], Yeom M[SUP]2[/SUP], Park G[SUP]1[/SUP], Kang A[SUP]2[/SUP], Chun H[SUP]1[/SUP], Park C[SUP]1[/SUP], Oh S[SUP]2[/SUP], Le VP[SUP]3[/SUP], Jeong HH[SUP]4[/SUP], Song D[SUP]2[/SUP], Haam S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.
[h=4]KEYWORDS:[/h] adjuvants; poly(amino acid); poly-l-lysine; squalene; vaccines
PMID: 30549426 DOI: 10.1002/adhm.201800953
[h=1]Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus.[/h] Lim JW[SUP]1[/SUP], Na W[SUP]2[/SUP], Kim HO[SUP]2[/SUP], Yeom M[SUP]2[/SUP], Park G[SUP]1[/SUP], Kang A[SUP]2[/SUP], Chun H[SUP]1[/SUP], Park C[SUP]1[/SUP], Oh S[SUP]2[/SUP], Le VP[SUP]3[/SUP], Jeong HH[SUP]4[/SUP], Song D[SUP]2[/SUP], Haam S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.
[h=4]KEYWORDS:[/h] adjuvants; poly(amino acid); poly-l-lysine; squalene; vaccines
PMID: 30549426 DOI: 10.1002/adhm.201800953