tetano
Editor, Senior Moderator
Immunity. 2014 Oct 8. pii: S1074-7613(14)00341-0. doi: 10.1016/j.immuni.2014.09.007. [Epub ahead of print]
CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection.
Laidlaw BJ1, Zhang N2, Marshall HD1, Staron MM1, Guan T1, Hu Y3, Cauley LS3, Craft J4, Kaech SM5.
Author information
Abstract
Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4+ T cells are important for the formation of functional lung-resident CD8+ T cells after influenza virus infection. In the absence of CD4+ T cells, CD8+ T cells displayed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrated an impaired ability to recruit CD8+ T cells to the lung airways upon heterosubtypic challenge. CD4+ T cell-derived interferon-γ was necessary for generating lung-resident CD103+ CD8+ Trm cells. Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4+ T cell help. Thus, CD4+ T cell-dependent signals are important to limit expression of T-bet and allow for the development of CD103+ CD8+ Trm cells in the lung airways following respiratory infection.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
25308332
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25308332
CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection.
Laidlaw BJ1, Zhang N2, Marshall HD1, Staron MM1, Guan T1, Hu Y3, Cauley LS3, Craft J4, Kaech SM5.
Author information
Abstract
Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4+ T cells are important for the formation of functional lung-resident CD8+ T cells after influenza virus infection. In the absence of CD4+ T cells, CD8+ T cells displayed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrated an impaired ability to recruit CD8+ T cells to the lung airways upon heterosubtypic challenge. CD4+ T cell-derived interferon-γ was necessary for generating lung-resident CD103+ CD8+ Trm cells. Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4+ T cell help. Thus, CD4+ T cell-dependent signals are important to limit expression of T-bet and allow for the development of CD103+ CD8+ Trm cells in the lung airways following respiratory infection.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
25308332
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25308332