tetano
Editor, Senior Moderator
Mediators Inflamm. 2019 Jan 10;2019:3231696. doi: 10.1155/2019/3231696. eCollection 2019.
[h=1]CD4[SUP]+[/SUP] TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice.[/h] Wu K[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Wang F[SUP]1,[/SUP][SUP]2[/SUP], Guo G[SUP]2[/SUP], Li Y[SUP]2,[/SUP][SUP]3[/SUP], Qiu LJ[SUP]4[/SUP], Li X[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122[SUP]high[/SUP] stem cell antigen-1 (Sca-1) [SUP]high[/SUP] B cell lymphoma 2 (Bcl-2) [SUP]high[/SUP] CD4[SUP]+[/SUP] stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Interestingly, the natural CD4[SUP]+[/SUP] TSCMs homing to the BM colocalized with VCAM-1[SUP]+[/SUP] IL-15[SUP]+[/SUP] IL-7[SUP]+[/SUP] CXCL-12[SUP]+[/SUP] stromal cells. Furthermore, compared to spleen-resident CD4[SUP]+[/SUP] TSCMs, BM-resident TSCMs induced the production of high-affinity antibodies against influenza by B lymphocytes more efficiently. Taken together, these observations indicate that the BM provides an appropriate microenvironment for the survival of CD4[SUP]+[/SUP] TSCMs, which broadens our knowledge regarding the memory maintenance of antigen-specific CD4[SUP]+[/SUP] T lymphocytes.
PMID: 30733641 PMCID: PMC6348795 DOI: 10.1155/2019/3231696
Free PMC Article
[h=1]CD4[SUP]+[/SUP] TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice.[/h] Wu K[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Wang F[SUP]1,[/SUP][SUP]2[/SUP], Guo G[SUP]2[/SUP], Li Y[SUP]2,[/SUP][SUP]3[/SUP], Qiu LJ[SUP]4[/SUP], Li X[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122[SUP]high[/SUP] stem cell antigen-1 (Sca-1) [SUP]high[/SUP] B cell lymphoma 2 (Bcl-2) [SUP]high[/SUP] CD4[SUP]+[/SUP] stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Interestingly, the natural CD4[SUP]+[/SUP] TSCMs homing to the BM colocalized with VCAM-1[SUP]+[/SUP] IL-15[SUP]+[/SUP] IL-7[SUP]+[/SUP] CXCL-12[SUP]+[/SUP] stromal cells. Furthermore, compared to spleen-resident CD4[SUP]+[/SUP] TSCMs, BM-resident TSCMs induced the production of high-affinity antibodies against influenza by B lymphocytes more efficiently. Taken together, these observations indicate that the BM provides an appropriate microenvironment for the survival of CD4[SUP]+[/SUP] TSCMs, which broadens our knowledge regarding the memory maintenance of antigen-specific CD4[SUP]+[/SUP] T lymphocytes.
PMID: 30733641 PMCID: PMC6348795 DOI: 10.1155/2019/3231696
Free PMC Article