tetano
Editor, Senior Moderator
Blood. 2013 May 29. [Epub ahead of print]
CD40L expression permits CD8+ T cells to execute immunological helper functions.
Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz AR, Stervbo U, J?rchott K, Gebhardt F, Heine G, Reuter MA, Betts MR, Busch D, Thiel A.
Source
Regenerative Immunology and Aging, Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine, Berlin, Germany;
Abstract
CD8+ T cells play an essential role in immunity against intracellular pathogens with cytotoxicity being considered their major effector mechanism. However, we here demonstrate that a major part of central and effector memory CD8+ T cells expresses CD40L, one key molecule for CD4+ T cell mediated help. CD40L+ CD8+ T cells are detectable among human antigen-specific immune responses including pathogens such as influenza and yellow fever virus. CD40L+ CD8+ T cells display potent helper functions in vitro and in vivo such as activation of APCs and exhibit a cytokine expression signature similar to CD4+ T cells and unrelated to cytotoxic CD8+ T cells. The broad occurrence of CD40L+ CD8+ T cells in cellular immunity implicates that helper functions are not only executed by MHC-II restricted CD4+ T helper cells but are also a common feature of MHC-I restricted CD8+ T cell responses. Due to their versatile functional capacities, human CD40L+ CD8+ T cells are promising candidate cells for immune therapies, particularly when CD4+ T cell help or pathogen-associated molecular pattern signals are limited.
PMID:
23719298
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23719298
CD40L expression permits CD8+ T cells to execute immunological helper functions.
Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz AR, Stervbo U, J?rchott K, Gebhardt F, Heine G, Reuter MA, Betts MR, Busch D, Thiel A.
Source
Regenerative Immunology and Aging, Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine, Berlin, Germany;
Abstract
CD8+ T cells play an essential role in immunity against intracellular pathogens with cytotoxicity being considered their major effector mechanism. However, we here demonstrate that a major part of central and effector memory CD8+ T cells expresses CD40L, one key molecule for CD4+ T cell mediated help. CD40L+ CD8+ T cells are detectable among human antigen-specific immune responses including pathogens such as influenza and yellow fever virus. CD40L+ CD8+ T cells display potent helper functions in vitro and in vivo such as activation of APCs and exhibit a cytokine expression signature similar to CD4+ T cells and unrelated to cytotoxic CD8+ T cells. The broad occurrence of CD40L+ CD8+ T cells in cellular immunity implicates that helper functions are not only executed by MHC-II restricted CD4+ T helper cells but are also a common feature of MHC-I restricted CD8+ T cell responses. Due to their versatile functional capacities, human CD40L+ CD8+ T cells are promising candidate cells for immune therapies, particularly when CD4+ T cell help or pathogen-associated molecular pattern signals are limited.
PMID:
23719298
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23719298