tetano
Editor, Senior Moderator
Cell Death Discov
. 2021 Mar 1;7(1):43.
doi: 10.1038/s41420-021-00428-w.
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
Andr? C Ferreira[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Vinicius Cardoso Soares[SUP] #[/SUP][SUP] 4 5 [/SUP], Isaclaudia G de Azevedo-Quintanilha[SUP] 4 [/SUP], Suelen da Silva Gomes Dias[SUP] 4 [/SUP], Natalia Fintelman-Rodrigues[SUP] 4 6 [/SUP], Carolina Q Sacramento[SUP] 4 6 [/SUP], Mayara Mattos[SUP] 4 6 [/SUP], Caroline S de Freitas[SUP] 4 6 [/SUP], Jairo R Temerozo[SUP] 7 8 [/SUP], L?via Teixeira[SUP] 4 [/SUP], Eugenio Damaceno Hottz[SUP] 4 9 [/SUP], Ester A Barreto[SUP] 4 [/SUP], Camila R R P?o[SUP] 4 [/SUP], Lohanna Palhinha[SUP] 4 [/SUP], Milene Miranda[SUP] 10 [/SUP], Dumith Chequer Bou-Habib[SUP] 7 8 [/SUP], Fernando A Bozza[SUP] 11 12 [/SUP], Patr?cia T Bozza[SUP] 4 [/SUP], Thiago Moreno L Souza[SUP] 13 14 [/SUP]
Affiliations
Abstract
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1? production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.
. 2021 Mar 1;7(1):43.
doi: 10.1038/s41420-021-00428-w.
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
Andr? C Ferreira[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Vinicius Cardoso Soares[SUP] #[/SUP][SUP] 4 5 [/SUP], Isaclaudia G de Azevedo-Quintanilha[SUP] 4 [/SUP], Suelen da Silva Gomes Dias[SUP] 4 [/SUP], Natalia Fintelman-Rodrigues[SUP] 4 6 [/SUP], Carolina Q Sacramento[SUP] 4 6 [/SUP], Mayara Mattos[SUP] 4 6 [/SUP], Caroline S de Freitas[SUP] 4 6 [/SUP], Jairo R Temerozo[SUP] 7 8 [/SUP], L?via Teixeira[SUP] 4 [/SUP], Eugenio Damaceno Hottz[SUP] 4 9 [/SUP], Ester A Barreto[SUP] 4 [/SUP], Camila R R P?o[SUP] 4 [/SUP], Lohanna Palhinha[SUP] 4 [/SUP], Milene Miranda[SUP] 10 [/SUP], Dumith Chequer Bou-Habib[SUP] 7 8 [/SUP], Fernando A Bozza[SUP] 11 12 [/SUP], Patr?cia T Bozza[SUP] 4 [/SUP], Thiago Moreno L Souza[SUP] 13 14 [/SUP]
Affiliations
- PMID: 33649297
- DOI: 10.1038/s41420-021-00428-w
Abstract
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1? production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.