tetano
Editor, Senior Moderator
Cell Host Microbe
. 2021 May 21;S1931-3128(21)00238-9.
doi: 10.1016/j.chom.2021.05.010. Online ahead of print.
SARS-CoV-2 human T cell epitopes: adaptive immune response against COVID-19
Alba Grifoni[SUP] 1 [/SUP], John Sidney[SUP] 1 [/SUP], Randi Vita[SUP] 1 [/SUP], Bjoern Peters[SUP] 2 [/SUP], Shane Crotty[SUP] 2 [/SUP], Daniela Weiskopf[SUP] 1 [/SUP], Alessandro Sette[SUP] 3 [/SUP]
Affiliations
Abstract
Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.
Keywords: CD4; CD8; SARS-CoV-2; T cells; epitopes.
. 2021 May 21;S1931-3128(21)00238-9.
doi: 10.1016/j.chom.2021.05.010. Online ahead of print.
SARS-CoV-2 human T cell epitopes: adaptive immune response against COVID-19
Alba Grifoni[SUP] 1 [/SUP], John Sidney[SUP] 1 [/SUP], Randi Vita[SUP] 1 [/SUP], Bjoern Peters[SUP] 2 [/SUP], Shane Crotty[SUP] 2 [/SUP], Daniela Weiskopf[SUP] 1 [/SUP], Alessandro Sette[SUP] 3 [/SUP]
Affiliations
- PMID: 34237248
- PMCID: PMC8139264
- DOI: 10.1016/j.chom.2021.05.010
Abstract
Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.
Keywords: CD4; CD8; SARS-CoV-2; T cells; epitopes.