tetano
Editor, Senior Moderator
Cell Immunol
. 2022 Jun 9;378:104562.
doi: 10.1016/j.cellimm.2022.104562. Online ahead of print.
Immune system changes in those with hypertension when infected with SARS-CoV-2
Sheng Su 2[SUP] 1 [/SUP], Ruirong Chen[SUP] 2 [/SUP], Shaofen Zhang[SUP] 3 [/SUP], Haihua Shu[SUP] 4 [/SUP], Jianfang Luo[SUP] 5 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) outbreak has become an evolving global health crisis. With an increasing incidence of primary hypertension, there is greater awareness of the relationship between primary hypertension and the immune system [including CD4+, CD8+ T cells, interleukin-17 (IL-17)/T regulatory cells (Treg) balance, macrophages, natural killer (NK) cells, neutrophils, B cells, and cytokines]. Hypertension is associated with an increased risk of various infections, post-infection complications, and increased mortality from severe infections. Despite ongoing reports on the epidemiological and clinical features of COVID-19, no articles have systematically addressed the role of primary hypertension in COVID-19 or how COVID-19 affects hypertension or specific treatment in these high-risk groups. Here, we synthesize recent advances in understanding the relationship between primary hypertension and COVID-19 and its underlying mechanisms and provide specific treatment guidelines for these high-risk groups.
Keywords: COVID-19; Hypertension; Immune system; SARS-CoV-2; Treatment.
. 2022 Jun 9;378:104562.
doi: 10.1016/j.cellimm.2022.104562. Online ahead of print.
Immune system changes in those with hypertension when infected with SARS-CoV-2
Sheng Su 2[SUP] 1 [/SUP], Ruirong Chen[SUP] 2 [/SUP], Shaofen Zhang[SUP] 3 [/SUP], Haihua Shu[SUP] 4 [/SUP], Jianfang Luo[SUP] 5 [/SUP]
Affiliations
- PMID: 35901625
- DOI: 10.1016/j.cellimm.2022.104562
Abstract
The coronavirus disease 2019 (COVID-19) outbreak has become an evolving global health crisis. With an increasing incidence of primary hypertension, there is greater awareness of the relationship between primary hypertension and the immune system [including CD4+, CD8+ T cells, interleukin-17 (IL-17)/T regulatory cells (Treg) balance, macrophages, natural killer (NK) cells, neutrophils, B cells, and cytokines]. Hypertension is associated with an increased risk of various infections, post-infection complications, and increased mortality from severe infections. Despite ongoing reports on the epidemiological and clinical features of COVID-19, no articles have systematically addressed the role of primary hypertension in COVID-19 or how COVID-19 affects hypertension or specific treatment in these high-risk groups. Here, we synthesize recent advances in understanding the relationship between primary hypertension and COVID-19 and its underlying mechanisms and provide specific treatment guidelines for these high-risk groups.
Keywords: COVID-19; Hypertension; Immune system; SARS-CoV-2; Treatment.