tetano
Editor, Senior Moderator
Cell Insight
. 2024 Jan 30;3(1):100144.
doi: 10.1016/j.cellin.2023.100144. eCollection 2024 Feb. Development of SARS-CoV-2 entry antivirals
Meiyue Dong[SUP] 1 [/SUP], Jazmin M Galvan Achi[SUP] 2 [/SUP], Ruikun Du[SUP] 1 3 [/SUP], Lijun Rong[SUP] 2 [/SUP], Qinghua Cui[SUP] 1 3 [/SUP]
Affiliations
The global outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatened human health and public safety. The development of anti-SARS-CoV-2 therapies have been essential to curb the spread of SARS-CoV-2. Particularly, antivirals targeting viral entry have become an attractive target for the development of anti-SARS-CoV-2 therapies. In this review, we elucidate the mechanism of SARS-CoV-2 viral entry and summarize the development of antiviral inhibitors targeting viral entry. Moreover, we speculate upon future directions toward more potent inhibitors of SARS-CoV-2 entry. This study is expected to provide novel insights for the efficient discovery of promising candidate drugs against the entry of SARS-CoV-2, and contribute to the development of broad-spectrum anti-coronavirus drugs.
Keywords: Antiviral inhibitors; Cell entry; SARS-CoV-2; SARS-CoV-2 variants.
. 2024 Jan 30;3(1):100144.
doi: 10.1016/j.cellin.2023.100144. eCollection 2024 Feb. Development of SARS-CoV-2 entry antivirals
Meiyue Dong[SUP] 1 [/SUP], Jazmin M Galvan Achi[SUP] 2 [/SUP], Ruikun Du[SUP] 1 3 [/SUP], Lijun Rong[SUP] 2 [/SUP], Qinghua Cui[SUP] 1 3 [/SUP]
Affiliations
- PMID: 38323318
- PMCID: PMC10844678
- DOI: 10.1016/j.cellin.2023.100144
The global outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatened human health and public safety. The development of anti-SARS-CoV-2 therapies have been essential to curb the spread of SARS-CoV-2. Particularly, antivirals targeting viral entry have become an attractive target for the development of anti-SARS-CoV-2 therapies. In this review, we elucidate the mechanism of SARS-CoV-2 viral entry and summarize the development of antiviral inhibitors targeting viral entry. Moreover, we speculate upon future directions toward more potent inhibitors of SARS-CoV-2 entry. This study is expected to provide novel insights for the efficient discovery of promising candidate drugs against the entry of SARS-CoV-2, and contribute to the development of broad-spectrum anti-coronavirus drugs.
Keywords: Antiviral inhibitors; Cell entry; SARS-CoV-2; SARS-CoV-2 variants.